Draelos Zoe, Lewis Joseph, McHugh Laura, Pellegrino Arthur, Popescu Lavinia
Dermatology Consulting Services, High Point, NC, USA.
US CosmeceuTechs, LLC, Richmond, VA, USA.
J Cosmet Dermatol. 2016 Mar;15(1):36-42. doi: 10.1111/jocd.12190. Epub 2015 Oct 30.
Retinoids (RC), alpha-hydroxy acids (AHA), and salicylic acid (BHA) treat acne through differing mechanisms of action. It is theorized that optimal improvement can be achieved by combining the RC-induced normalization of cellular differentiation, AHA-induced exfoliation in hydrophilic areas, and BHA-induced exfoliation in lipophilic areas. AHA and RC have been combined in a bioengineered molecule (AHA retinoid conjugate, or AHA-RC) delivering both lactic acid (AHA) and RC in a manner reducing retinoid-associated irritation.
To evaluate efficacy and tolerability of a twice-daily, three-product skincare regimen using AHA-RC in combination with BHA for patients with acne.
A total of 27 women (age range 20-58 years, mean 37.81 ± 10.04 years) with mild-to-moderate acne used a 3-product regimen consisting of a twice-daily cleanser and topical serum (0.1% AHA-RC, 2% salicylic acid, and 10.4% l-lactic acid), with broad-spectrum SPF 50+ sunscreen as needed, over an 8-week period. Counts were made at baseline, week 4, and week 8 of total inflammatory (papules, pustules) and noninflammatory (open comedones, closed comedones) lesions. Dryness, stinging, and other secondary endpoints were rated on a 0-5 scale.
Statistically significant reduction in inflammatory and noninflammatory lesion counts (P = 0.006 and P = 0.015, respectively) was noted at 4 weeks. Improvement continued into week 8 with highly significant (P < 0.001) reductions in both lesion counts.
The topical combination of lactic acid, SA, and AHA-RC produced acne improvement after 4 weeks with continuing cumulative improvement at 8 weeks. AHA-RC represents a new molecule combining several mechanisms of action to achieve acne improvement.
维甲酸（RC）、α-羟基酸（AHA）和水杨酸（BHA）通过不同的作用机制治疗痤疮。理论上，通过联合RC诱导的细胞分化正常化、AHA诱导的亲水区角质剥脱以及BHA诱导的亲脂区角质剥脱，可实现最佳改善效果。AHA和RC已被组合成一种生物工程分子（AHA维甲酸共轭物，或AHA-RC），以一种减少维甲酸相关刺激的方式递送乳酸（AHA）和RC。
评估一种每日两次、三种产品的护肤方案，即AHA-RC联合BHA用于痤疮患者的疗效和耐受性。
共有27名年龄在20至58岁（平均37.81±10.04岁）的轻度至中度痤疮女性患者，在8周内使用一种三件套护肤方案，包括每日两次使用的洁面产品和外用精华液（0.1%AHA-RC、2%水杨酸和10.4%左旋乳酸），并根据需要使用广谱SPF 50+防晒霜。在基线、第4周和第8周时，对总的炎性（丘疹、脓疱）和非炎性（开放性粉刺、闭合性粉刺）皮损进行计数。干燥、刺痛和其他次要终点按0至5级进行评分。
在第4周时，炎性和非炎性皮损计数有统计学意义的减少（分别为P = 0.006和P = 0.015）。改善持续到第8周，两种皮损计数均有高度显著的减少（P < 0.001）。
乳酸、SA和AHA-RC的局部联合使用在4周后改善了痤疮情况，并在8周时有持续的累积改善。AHA-RC代表了一种结合多种作用机制以改善痤疮的新分子。
