通过烷基化和迁移脱羧芳基化实现炔酸酯的氧化双官能团化
Oxidative Difunctionalization of Alkynoates through Alkylation and Migration Decarboxylative Arylation.
作者信息
Ni Shengyang, Zhang Yu, Xie Chen, Mei Haibo, Han Jianlin, Pan Yi
机构信息
School of Chemistry and Chemical Engineering, State Key laboratory of Coordination Chemistry, Nanjing University , Nanjing, 210093, China.
MaAnShan High-Tech Research Institute of Nanjing University, MaAnShan, 238200, China.
出版信息
Org Lett. 2015 Nov 20;17(22):5524-7. doi: 10.1021/acs.orglett.5b02356. Epub 2015 Oct 30.
A cascade oxidative difunctionalization reaction of alkynoates for the construction of trisubstituted olefins has been developed. The process undergoes alkylation of a C-C triple bond, 1,4-aryl migration, and decarboxylation, which demonstrates a multistep radical cascade reaction for the difunctionalization of alkynoates and also represents a strategy of direct decarboxylation of esters.
已开发出一种用于构建三取代烯烃的炔酸酯级联氧化双官能化反应。该过程经历碳 - 碳三键的烷基化、1,4 - 芳基迁移和脱羧反应，这展示了一种用于炔酸酯双官能化的多步自由基级联反应，同时也代表了一种酯直接脱羧的策略。
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