Ni Shengyang, Zhang Yu, Xie Chen, Mei Haibo, Han Jianlin, Pan Yi
School of Chemistry and Chemical Engineering, State Key laboratory of Coordination Chemistry, Nanjing University , Nanjing, 210093, China.
MaAnShan High-Tech Research Institute of Nanjing University, MaAnShan, 238200, China.
Org Lett. 2015 Nov 20;17(22):5524-7. doi: 10.1021/acs.orglett.5b02356. Epub 2015 Oct 30.
A cascade oxidative difunctionalization reaction of alkynoates for the construction of trisubstituted olefins has been developed. The process undergoes alkylation of a C-C triple bond, 1,4-aryl migration, and decarboxylation, which demonstrates a multistep radical cascade reaction for the difunctionalization of alkynoates and also represents a strategy of direct decarboxylation of esters.
已开发出一种用于构建三取代烯烃的炔酸酯级联氧化双官能化反应。该过程经历碳 - 碳三键的烷基化、1,4 - 芳基迁移和脱羧反应，这展示了一种用于炔酸酯双官能化的多步自由基级联反应，同时也代表了一种酯直接脱羧的策略。
