Poce Giovanna, Biava Mariangela
Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, piazzale Aldo Moro 5, I-00185 Roma, Italy.
Future Microbiol. 2015;10(11):1735-41. doi: 10.2217/fmb.15.76. Epub 2015 Oct 30.
Despite enormous progress, tuberculosis (TB) is still a major global health problem. Poor patients' adherence to the current treatment leads to the emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) strains. While increased numbers of MDR-TB cases can be ascribed to difficulties in treating TB-HIV coinfected patients, many studies demonstrated that the emergence of drug-resistant TB is clearly linked to misdiagnosis and mismanagement of drug-susceptible TB. Therefore, rapid detection and proper treatment are needed globally to both cure TB patients and prevent wide spreading of the disease. This paper provides a survey of the major strategies that have been explored for overcoming drug resistance in TB.
尽管取得了巨大进展，但结核病仍然是一个重大的全球健康问题。患者对当前治疗的依从性差导致了多重耐药（MDR）和广泛耐药（XDR）菌株的出现。虽然耐多药结核病病例数量的增加可归因于治疗结核病合并感染艾滋病毒患者的困难，但许多研究表明，耐药结核病的出现显然与药物敏感结核病的误诊和管理不当有关。因此，全球都需要进行快速检测和适当治疗，以治愈结核病患者并防止疾病的广泛传播。本文综述了为克服结核病耐药性而探索的主要策略。
