Gao L, Wang H, Xu Y, Zhang Z
Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing, China.
Department of Radiology, Peking University First Hospital, Beijing, China.
Clin Exp Rheumatol. 2015 Nov-Dec;33(6):871-6. Epub 2015 Oct 30.
To discover the relationship between computed tomography (CT) parameters of retroperitoneal soft tissue of untreated retroperitoneal fibrosis patients and the variation of renal function after treatment.
Data were collected retrospectively from 42 patients with established diagnosis of retroperitoneal fibrosis, at the Department of Rheumatology in Peking University First Hospital from May 2009 to April 2015. The demographic information, clinical characteristics, laboratory data, treatment and general therapeutic response were collected. The CT parameters such as radial lines, Hounsfield unit values, radiographic classification at baseline before the initiation of therapy were measured. Then the correlations between baseline CT parameters and clinical data were analysed.
The Hounsfield unit values of venous phase and delayed phase at baseline were negatively correlated with the change of estimated glomerular filtration rate (eGFR) at the 12th month after the initiation of medications. The baseline transverse diameters of the retroperitoneal soft tissue were larger in the group of eGFR <60 ml/min/1.73 m² compared with the group of eGFR ≥ 60 ml/min/1.73 m² at the 12th month, while the vertical diameters and maximum cross-section thickness were not. The baseline transverse diameters were also significantly correlated with the duration of intubation.
The baseline Hounsfield unit values and baseline transverse diameters of soft tissue of untreated retroperitoneal fibrosis patients may be used to predict the renal function after 12 months of therapy.
探究未经治疗的腹膜后纤维化患者腹膜后软组织的计算机断层扫描（CT）参数与治疗后肾功能变化之间的关系。
回顾性收集2009年5月至2015年4月北京大学第一医院风湿免疫科确诊为腹膜后纤维化的42例患者的数据。收集人口统计学信息、临床特征、实验室数据、治疗及总体治疗反应。测量治疗开始前基线时的CT参数，如径向线、亨氏单位值、影像学分类。然后分析基线CT参数与临床数据之间的相关性。
基线时静脉期和延迟期的亨氏单位值与开始用药后第12个月的估计肾小球滤过率（eGFR）变化呈负相关。在第12个月时，eGFR<60 ml/min/1.73 m²组的腹膜后软组织基线横径大于eGFR≥60 ml/min/1.73 m²组，而垂直径和最大截面厚度则不然。基线横径也与插管持续时间显著相关。
未经治疗的腹膜后纤维化患者的基线亨氏单位值和软组织基线横径可用于预测治疗12个月后的肾功能。
