Moura Tiane Martin de, Campos Fabrício Souza, Caierão Juliana, Franco Ana Claudia, Roehe Paulo Michel, d'Azevedo Pedro Alves, Frazzon Jeverson, Frazzon Ana Paula Guedes
Departamento Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Departamento de Microbiologia, Parasitologia e Imunologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Rev Soc Bras Med Trop. 2015 Sep-Oct;48(5):617-21. doi: 10.1590/0037-8682-0017-2015.
Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome.
Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin.
A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro .
Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains.
接触亚抑菌浓度（SICs）的抗菌药物可能会改变细菌转录组。
在此，我们评估了在万古霉素亚抑菌浓度下生长的耐万古霉素肠球菌（VRE）尿路感染分离株中九个毒力相关基因的表达。
万古霉素的亚抑菌浓度会干扰基因调控，但在体外不影响VRE菌株的表型。
万古霉素的亚抑菌浓度可能在体内调节毒力因子的表达或有助于耐万古霉素菌株的选择。
