miR-24-Bim 通路促进胰腺癌的肿瘤生长和血管生成。
The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma.
作者信息
Liu Rui, Zhang Haiyang, Wang Xia, Zhou Likun, Li Hongli, Deng Ting, Qu Yanjun, Duan Jingjing, Bai Ming, Ge Shaohua, Ning Tao, Zhang Le, Huang Dingzhi, Ba Yi
机构信息
Department of Gastrointestinal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
出版信息
Oncotarget. 2015 Dec 22;6(41):43831-42. doi: 10.18632/oncotarget.6257.
miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And Bim-related miR-24 is significantly up-regulated in PaC. The repressed expression of Bim is proved to be a result of miR-24, thus promoting cell growth of both cancer and vascular cells, and accelerating vascular ring formation. By using mouse tumor model, we clearly showed that miR-24 promotes tumor growth and angiogenesis by suppressing Bim expression in vivo. Therefore, a new pathway comprising miR-24 and Bim can be used in the exploration of drug-target therapy of PaC.
微小RNA（miRNAs）是一类小RNA，据报道它们在肿瘤发生的各个阶段都发挥着关键作用，并且被认为具有未来的实际应用价值。我们现在证明，刺激细胞凋亡的Bim在胰腺癌（PaC）组织和细胞系中明显下调。而与Bim相关的miR-24在PaC中显著上调。事实证明，Bim的表达受抑制是miR-24作用的结果，从而促进癌细胞和血管细胞的生长，并加速血管环的形成。通过使用小鼠肿瘤模型，我们清楚地表明，miR-24在体内通过抑制Bim表达促进肿瘤生长和血管生成。因此，由miR-24和Bim组成的新途径可用于探索PaC的药物靶向治疗。
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