来自圆柱紫茎泽兰的对映贝壳杉烯糖苷。

ent-Kaurene Glycosides from Ageratina cylindrica.

作者信息

Bustos-Brito Celia, Sánchez-Castellanos Mariano, Esquivel Baldomero, Calderón José S, Calzada Fernando, Yépez-Mulia Lilian, Joseph-Nathan Pedro, Cuevas Gabriel, Quijano Leovigildo

机构信息

Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria , México, D.F. 04510, México.

Unidad de Investigación Médica en Farmacología, 2° Piso CORCE, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS , Avenida Cuauhtémoc 330, Col. Doctores, México, D.F. 06725, México.

出版信息

J Nat Prod. 2015 Nov 25;78(11):2580-7. doi: 10.1021/acs.jnatprod.5b00488. Epub 2015 Oct 30.

DOI:10.1021/acs.jnatprod.5b00488

PMID:26517282

Abstract

The aqueous extract of the leaves of Ageratina cylindrica afforded six new ent-kaurenoic acid glycosides together with the known diterpenoid paniculoside V, the flavonoid astragalin, chlorogenic acid, and L-chiro-inositol. The structures were elucidated mainly by NMR and MS methods, and the absolute configuration was established by vibrational circular dichroism spectroscopy. The new compounds showed moderate antiprotozoal activity against Entamoeba histolytica and Giardia lamblia trophozoites.

摘要

圆柱紫茎泽兰叶的水提取物得到了六种新的对映-贝壳杉烯酸糖苷，以及已知的二萜类化合物paniculoside V、黄酮类化合物紫云英苷、绿原酸和L-手性肌醇。主要通过核磁共振（NMR）和质谱（MS）方法阐明了其结构，并通过振动圆二色光谱确定了绝对构型。这些新化合物对溶组织内阿米巴和蓝氏贾第鞭毛虫滋养体显示出中等程度的抗原虫活性。