Tan Wylie, Wright Tom, Rajendran Durgaa, Garcia-Sanchez Yaiza, Finkelberg Laura, Kisilak Marsha, Campbell Melanie, Westall Carol A
Department of Ophthalmology and Vision Sciences, The Hospital For Sick Children, Toronto, Canada 2School of Optometry and Vision Science, University of Waterloo, Waterloo, Canada.
Department of Ophthalmology and Vision Sciences, The Hospital For Sick Children, Toronto, Canada.
Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6339-43. doi: 10.1167/iovs.15-16817.
Changes to retinal structure and function occur in individuals with diabetes before the onset of diabetic retinopathy. It is still unclear if these changes initially affect vascular or neural retina, or if particular retinal areas are more susceptible than others. This paper examines the distribution of cone photoreceptor density in the retina of adolescents with type 1 diabetes.
This cross-sectional prospective study includes 29 adolescents and young adults with type 1 diabetes and no diabetic retinopathy and 44 control participants recruited at the Hospital for Sick Children. Adaptive-optics enhanced retinal imaging of the cone photoreceptor mosaic was performed in four quadrants at an eccentricity of ∼7° from the fovea. After image registration and averaging, cone photoreceptors were counted and photoreceptor density was calculated. Analysis of variance with repeated measures was used to assess the differences in photoreceptor density between groups.
Cone density was similar in both control participants and participants with diabetes. There was a small effect of retinal hemisphere; participants with diabetes did not show the expected radial asymmetry observed in control participants.
Cone density in the parafoveal retina is not reduced in adolescents with type 1 diabetes.
在糖尿病性视网膜病变发作之前，糖尿病患者的视网膜结构和功能就会发生变化。目前仍不清楚这些变化最初是影响血管性视网膜还是神经性视网膜，或者特定的视网膜区域是否比其他区域更易受影响。本文研究了1型糖尿病青少年视网膜中视锥光感受器密度的分布情况。
这项横断面前瞻性研究纳入了29名患有1型糖尿病且无糖尿病性视网膜病变的青少年和青年，以及在病童医院招募的44名对照参与者。在距中央凹约7°的四个象限中，采用自适应光学增强视网膜成像技术对视锥光感受器镶嵌图进行成像。在图像配准和平均处理后，对视锥光感受器进行计数并计算光感受器密度。采用重复测量方差分析来评估两组之间光感受器密度的差异。
对照参与者和糖尿病患者的视锥密度相似。视网膜半球存在较小的影响；糖尿病患者未表现出对照参与者中观察到的预期径向不对称性。
1型糖尿病青少年的中央凹旁视网膜视锥密度未降低。
