Kupis Magdalena, Wawrzyniak Zbigniew M, Szaflik Jacek P, Zaleska-Żmijewska Anna
Department of Ophthalmology, SPKSO Ophthalmic Hospital, Medical University of Warsaw, 02-097 Warsaw, Poland.
Faculty of Electronics and Information Technology, Warsaw University of Technology, 00-665 Warsaw, Poland.
Diagnostics (Basel). 2023 Jul 27;13(15):2513. doi: 10.3390/diagnostics13152513.
With the increasing global incidence of diabetes mellitus (DM), diabetic retinopathy (DR) has become one of the leading causes of blindness in developed countries. DR leads to changes in retinal neurons and microcirculation. Rtx1 (Imagine Eyes, Orsay, France) is a retinal camera that allows histological visualisations of cones and retinal microcirculation throughout the DM duration.
This study aimed to analyse the cones and retinal microvascular changes in 50 diabetic individuals and 18 healthy volunteers. The patients participated in the initial visit and two follow-up appointments, one and two years after the study, beginning with Rtx1 image acquisition, visual acuity assessment, macular OCT scans and blood measurements.
The study revealed significant differences in the cone density, mosaic arrangement and vascular morphology between healthy and diabetic patients. The final measurements showed decreased photoreceptor and microvascular parameters in the DR group compared with the control group. Furthermore, in the 2-year follow-up, both groups' Rtx1-acquired morphological changes were statistically significant.
Rtx1 technology was successfully used as a non-invasive method of photoreceptors and retinal vasculature assessment over time in patients with diabetic retinopathy. The study revealed a trend toward more vascular morphological changes occurring over time in diabetic patients.
随着全球糖尿病（DM）发病率的不断上升，糖尿病视网膜病变（DR）已成为发达国家失明的主要原因之一。DR会导致视网膜神经元和微循环发生变化。Rtx1（法国奥赛Imagine Eyes公司）是一款视网膜相机，可在糖尿病病程中对视锥细胞和视网膜微循环进行组织学可视化观察。
本研究旨在分析50名糖尿病患者和18名健康志愿者的视锥细胞和视网膜微血管变化。患者参与了初次就诊以及研究开始后1年和2年的两次随访，每次随访均进行Rtx1图像采集、视力评估、黄斑OCT扫描和血液检测。
研究发现，健康患者与糖尿病患者在视锥细胞密度、镶嵌排列和血管形态方面存在显著差异。最终测量结果显示，与对照组相比，DR组的光感受器和微血管参数有所下降。此外，在2年的随访中，两组通过Rtx1获得的形态学变化均具有统计学意义。
Rtx1技术成功地作为一种非侵入性方法，用于长期评估糖尿病视网膜病变患者的光感受器和视网膜血管系统。该研究揭示了糖尿病患者随着时间推移血管形态变化增多的趋势。
