Jin Haiqiang, Sun Wei, Sun Yongan, Huang Yining, Sun Yunchuang
Department of Neurology, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, 100034, PR China.
BMC Neurol. 2015 Oct 30;15:222. doi: 10.1186/s12883-015-0482-2.
Studies on the role of cold agglutinins in the pathogenesis of acute ischemic stroke are scarce. We present a case of an elderly man with acute cerebral infarction probably due to cold agglutinin disease.
On a cold morning, a 71-year-old male of Han nationality with a complaint of sudden onset left-sided weakness and difficulty in speaking was brought to the emergency department. Diffusion weighted magnetic resonance imaging of the brain showed a high-intensity area in the right basal ganglia and corona radiata. Laboratory test showed the presence of high titers of cold agglutinins. There was no history of common risk factors of atherosclerosis, such as hypertension, diabetes mellitus, coronary artery disease or smoking. After being exposed to warm temperature, and with corticosteroid therapy and blood transfusion, the patient's symptoms relieved rapidly.
We report here the first case of cerebral infarction probably due to the cold agglutinin disease. The underlying mechanism of cold agglutinins in the pathogenesis of acute ischemic stroke needs to be investigated further.
关于冷凝集素在急性缺血性中风发病机制中的作用的研究较少。我们报告一例可能因冷凝集素病导致急性脑梗死的老年男性病例。
在一个寒冷的早晨，一名71岁汉族男性因突发左侧肢体无力和言语困难被送至急诊科。脑部弥散加权磁共振成像显示右侧基底节和放射冠有高强度区域。实验室检查显示存在高滴度冷凝集素。患者无动脉粥样硬化常见危险因素史，如高血压、糖尿病、冠状动脉疾病或吸烟史。暴露于温暖环境并接受皮质类固醇治疗和输血后，患者症状迅速缓解。
我们在此报告首例可能因冷凝集素病导致的脑梗死病例。冷凝集素在急性缺血性中风发病机制中的潜在机制需要进一步研究。
