Zefirov T L, Khisamieva L I, Ziyatdinova N I, Zefirov A L
Department of Anatomy, Physiology, and Human Health Protection, Kazan State Medical University, Kazan, Republic of Tatarstan, Russia.
Department of Normal Physiology, Kazan State Medical University, Kazan, Republic of Tatarstan, Russia.
Bull Exp Biol Med. 2015 Oct;159(6):697-9. doi: 10.1007/s10517-015-3051-1. Epub 2015 Oct 31.
Selective blockade of α2C-adrenoceptors had different effects on the cardiovascular system in rats of various age groups. Blockade of α2C-adrenoceptors in adult rats and 3-week-old animals produced the positive and negative chronotropic effects, respectively. HR in 1-week-old and 6-week-old rats did not change during α2C-adrenoceptor blockade. Selective blockade of α2C-adrenoceptors in adult rats and 3-week-old animals was followed by the increase in BP. BP in 6-week-old rats was shown to decrease under these conditions.
