Zefirov T L, Khisamieva L I, Khabibrakhmanov I I, Ziyatdinova N I, Zefirov A L
Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia.
Department of Normal Physiology, Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Republic of Tatarstan, Russia.
Bull Exp Biol Med. 2023 Sep;175(5):612-615. doi: 10.1007/s10517-023-05911-1. Epub 2023 Oct 21.
We studied the effect of selective α-adrenergic receptor antagonist JP-1302 in concentrations of 10-10 M on inotropy, chronotropy, and coronary flow in the Langendorff-isolated rat heart. JP-1302 in all studied concentrations decreased the left-ventricular myocardium force contraction, HR, and coronary flow. The maximum inotropic, chronotropic, and vascular effects were observed when the antagonist was applied to the perfused solution in a concentration of 10 M. The least pronounced decrease in the studied parameters was observed at JP-1302 concentrations of 10 and 10 M. The obtained data indicate the participation of this subtype of α-adrenergic receptors in the regulation of activity of isolated adult rats heart.
我们研究了浓度为10⁻¹⁰ M的选择性α-肾上腺素能受体拮抗剂JP-1302对Langendorff离体大鼠心脏的心肌收缩力、心率和冠状动脉血流量的影响。在所研究的所有浓度下，JP-1302均降低了左心室心肌收缩力、心率和冠状动脉血流量。当拮抗剂以10⁻⁸ M的浓度加入到灌注液中时，观察到最大的心肌收缩力、心率和血管效应。在JP-1302浓度为10⁻¹⁰ M和10⁻⁹ M时，所研究参数的下降最为不明显。所得数据表明该亚型α-肾上腺素能受体参与了成年离体大鼠心脏活动的调节。
