Lumlertgul D, Keoplung M, Sitprija V, Moollaor P, Suwangool P
Department of Medicine, Chiang Mai University, Bangkok, Thailand.
Nephron. 1989;52(1):40-4. doi: 10.1159/000185580.
The effects of furosemide and furosemide with dopamine on renal function were studied in 23 patients with acute renal failure due to falciparum malaria whose serum creatinine ranged from 230 to 947 mumol/l. Furosemide given intravenously at the dosage of 200 mg 6 hourly for a period of 4 days did not alter the clinical course of renal failure. Intravenous administration of furosemide (200 mg 6 hourly) with dopamine (1 microgram/kg/min) for 4 days increased creatinine clearance and arrested the progress of renal failure when the serum creatinine was less than 400 mumol/l, but failed to alter the course of renal failure when the serum creatinine exceeded 600 mumol/l.
在23例因恶性疟原虫疟疾导致急性肾衰竭、血清肌酐水平在230至947微摩尔/升之间的患者中，研究了呋塞米及呋塞米联合多巴胺对肾功能的影响。以每6小时200毫克的剂量静脉注射呋塞米，持续4天，并未改变肾衰竭的临床病程。当血清肌酐低于400微摩尔/升时，静脉注射呋塞米（每6小时200毫克）联合多巴胺（1微克/千克/分钟）4天可增加肌酐清除率并阻止肾衰竭进展，但当血清肌酐超过600微摩尔/升时，则未能改变肾衰竭病程。
