McCracken G H, Mustafa M M, Ramilo O, Olsen K D, Risser R C
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas.
Pediatr Infect Dis J. 1989 Mar;8(3):155-9.
Concentrations of interleukin 1-beta and tumor necrosis factor in cerebrospinal fluid (CSF) of 42 neonates with Gram-negative enteric bacillary meningitis were determined and correlated with outcome and other CSF indices. At the time of diagnosis interleukin 1-beta was detected in CSF of 40 infants and peak concentrations correlated significantly with outcome from disease. Days of interleukin 1-beta concentrations of greater than 200 pg/ml or greater than or equal to 20 pg/ml were significantly correlated with days that CSF cultures were positive and that K1 antigen and endotoxin were detected in CSF. Tumor necrosis factor activity was detected in CSF of 25 of 27 infants; there was no correlation between outcome and CSF tumor necrosis factor concentrations. The results provide a possible rationale for therapeutic intervention to improve outcome.
测定了42例革兰氏阴性肠道杆菌脑膜炎新生儿脑脊液（CSF）中白细胞介素1-β和肿瘤坏死因子的浓度，并将其与预后及其他脑脊液指标进行关联分析。诊断时，在40例婴儿的脑脊液中检测到白细胞介素1-β，其峰值浓度与疾病预后显著相关。白细胞介素1-β浓度大于200 pg/ml或大于等于20 pg/ml的天数与脑脊液培养阳性天数以及脑脊液中检测到K1抗原和内毒素的天数显著相关。27例婴儿中有25例脑脊液中检测到肿瘤坏死因子活性；预后与脑脊液肿瘤坏死因子浓度之间无相关性。这些结果为改善预后的治疗干预提供了可能的理论依据。
