细菌性脑膜炎患者脑脊液中白细胞介素-1β、肿瘤坏死因子-α和干扰素-γ的浓度
Cerebrospinal fluid concentrations of interleukin-1 beta, tumour necrosis factor-alpha, and interferon gamma in bacterial meningitis.
作者信息
Ohga S, Aoki T, Okada K, Akeda H, Fujioka K, Ohshima A, Mori T, Minamishima I, Ueda K
机构信息
Department of Paediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
出版信息
Arch Dis Child. 1994 Feb;70(2):123-5. doi: 10.1136/adc.70.2.123.
To investigate the role of the inflammatory cytokines, the cerebrospinal fluid concentrations of interleukin (IL)-1 beta, tumour necrosis factor-alpha (TNF-alpha), and interferon gamma (IFN-gamma) were measured in 11 children with bacterial meningitis and two with mycoplasmic meningoencephalitis and compared with those in 50 children with aseptic meningitis and 15 with non-pleocytotic cerebrospinal fluid. Concentrations of IL-1 beta and TNF-alpha were each significantly higher in the cerebrospinal fluid of patients with bacterial meningitis than in those with aseptic meningitis or those with non-pleocytotic cerebrospinal fluid. IFN-gamma was detected at low concentrations in the cerebrospinal fluid of only 2/11 of those with bacterial meningitis. On the other hand, the IFN-gamma concentration was the highest in the cerebrospinal fluid of patients with aseptic meningitis. These results suggest that the inflammatory cytokines are differently released in the intrathecal space infected with viruses or bacteria.
为研究炎性细胞因子的作用，对11例细菌性脑膜炎患儿和2例支原体脑膜脑炎患儿的脑脊液中白细胞介素（IL）-1β、肿瘤坏死因子-α（TNF-α）和干扰素γ（IFN-γ）浓度进行了测定，并与50例无菌性脑膜炎患儿及15例脑脊液无细胞增多的患儿进行比较。细菌性脑膜炎患者脑脊液中IL-1β和TNF-α的浓度均显著高于无菌性脑膜炎患者或脑脊液无细胞增多的患者。仅2/11的细菌性脑膜炎患者脑脊液中检测到低浓度的IFN-γ。另一方面，无菌性脑膜炎患者脑脊液中IFN-γ浓度最高。这些结果表明，炎性细胞因子在病毒或细菌感染的鞘内空间释放方式不同。
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