在暴露于生理水平肾上腺素期间血栓素和前列环素的体内生物合成。

In vivo biosynthesis of thromboxane and prostacyclin during exposure to physiological levels of epinephrine.

作者信息

Vesterqvist O, Rasmanis G, Gréen K, Edhag O, Henriksson P

机构信息

Department of Clinical Chemistry and Blood Coagulation, Karolinska Hospital, Stockholm, Sweden.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 1989 Mar;35(3):165-7. doi: 10.1016/0952-3278(89)90119-1.

DOI:10.1016/0952-3278(89)90119-1

PMID:2652147

Abstract

The effects of 20-min epinephrine infusion (0.025 and 0.3 nmol/kg/min) on the in vivo synthesis of thromboxane A2 and prostacyclin were studied in ten healthy male volunteers. We assessed the in vivo biosynthesis of thromboxane A2 and prostacyclin by measurement of the urinary metabolites 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha, respectively. Epinephrine infusion did not cause any significant changes in the urinary excretion of the two metabolites. Thus, we conclude that physiological levels of epinephrine do not affect the in vivo biosynthesis of thromboxane A2 and prostacyclin.

摘要

在十名健康男性志愿者中研究了持续20分钟输注肾上腺素（0.025和0.3纳摩尔/千克/分钟）对血栓素A2和前列环素体内合成的影响。我们分别通过测量尿代谢产物2,3-二去甲血栓素B2和2,3-二去甲-6-酮-前列腺素F1α来评估血栓素A2和前列环素的体内生物合成。输注肾上腺素并未导致这两种代谢产物的尿排泄出现任何显著变化。因此，我们得出结论，生理水平的肾上腺素不会影响血栓素A2和前列环素的体内生物合成。