Ciurana Joaquim, Rodríguez Ciro A
Department of Mechanical Engineering and Civil Construction, Universitat de Girona, C/ Maria Aurèlia Capmany, 61, 17003 Girona, Spain.
Curr Drug Targets. 2017;18(2):135-146. doi: 10.2174/1389450116666151102094738.
For decades polyphenols have been considered to be sound, naturally occurring therapeutic compounds. While there are several polyphenols with special applications used in the treatment of cancer and other diseases, they need a specific carrier in order to reach the cells targeted for treatment. Recently, a number of new technologies have been developed on a nanoscale, such as nanoparticles, nanocapsules and nanofibers that can provide targeted delivery of polyphenols for medical purposes. This work summarizes the current trends in nanoscale delivery technology for polyphenols in cancer treatment and outlines its capabilities and the significant improvements that have been made. Special emphasis is given to the materials and to the manufacturing processes used to produce these kinds of drug delivery system nanostructures.
几十年来,多酚一直被认为是健康的天然治疗化合物。虽然有几种具有特殊应用的多酚用于治疗癌症和其他疾病,但它们需要特定的载体才能到达靶向治疗的细胞。最近,已经开发了许多纳米级的新技术,如纳米颗粒、纳米胶囊和纳米纤维,它们可以为医学目的提供多酚的靶向递送。这项工作总结了癌症治疗中多酚纳米级递送技术的当前趋势,并概述了其能力以及所取得的重大进展。特别强调了用于生产这类药物递送系统纳米结构的材料和制造工艺。