Chavez Carvajal Patricia, Coppo Erika, Di Lorenzo Arianna, Gozzini Davide, Bracco Francesco, Zanoni Giuseppe, Nabavi Seyed Mohammad, Marchese Anna, Arciola Carla Renata, Daglia Maria
Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Microbiology Unit, DISC, University of Genoa, IRCCS-San Martino IST, Largo Rosanna Benzi 10, 16132 Genoa, Italy.
Materials (Basel). 2016 Jun 7;9(6):454. doi: 10.3390/ma9060454.
(O. Berg) McVaugh (Myrtaceae) is a plant native to Ecuador, traditionally used for its antiseptic properties. The composition of the hydro-methanolic extract of this plant was determined by submitting it to ultra-high performance liquid chromatography (UHPLC) hyphenated to heated-electrospray ionization mass spectrometry and UV detection. The presence of antimicrobial components prompted us to test the extract against methicillin-resistant and methicillin-susceptible , multidrug-resistant and susceptible , , spp. and strains. The chromatographic analysis led to the identification of 38 compounds, including polyphenols and organic acids, and represents the first chemical characterization of this plant. The extract showed modest antibacterial activity against all tested bacteria, with the exception of which was found to be less sensitive. Whilst methicillin-resistant strains usually display resistance to several drugs, no relevant differences were observed between methicillin-susceptible and resistant strains. Considering its long-standing use in folk medicine, which suggests the relative safety of the plant, and the presence of many known antibacterial polyphenolic compounds responsible for its antibacterial activity, the results show that extract could be used as a potential new antiseptic agent. Moreover, new anti-infective biomaterials and nanomaterials could be designed through the incorporation of polyphenols. This prospective biomedical application is also discussed.
（O. 伯格）麦克沃（桃金娘科）是一种原产于厄瓜多尔的植物，传统上因其抗菌特性而被使用。通过将该植物的氢甲醇提取物进行超高效液相色谱（UHPLC）与加热电喷雾电离质谱联用及紫外检测，确定了其成分。抗菌成分的存在促使我们测试该提取物对耐甲氧西林和对甲氧西林敏感的、多重耐药和敏感的、、、 spp. 及菌株的效果。色谱分析鉴定出38种化合物，包括多酚和有机酸，这是该植物的首次化学表征。该提取物对所有测试细菌均显示出适度的抗菌活性，但发现对其不太敏感。虽然耐甲氧西林菌株通常对多种药物耐药，但在对甲氧西林敏感和耐药菌株之间未观察到相关差异。考虑到其在民间医学中的长期使用表明该植物相对安全，以及存在许多已知的负责其抗菌活性的抗菌多酚化合物，结果表明提取物可作为一种潜在的新型抗菌剂。此外，通过掺入多酚可以设计新的抗感染生物材料和纳米材料。还讨论了这种前瞻性的生物医学应用。
