Mel-Hennawi D, Ahmed M R
Otolaryngology Unit,Faculty of Medicine,Suez Canal University,Ismailia,Egypt.
J Laryngol Otol. 2015 Nov;129(11):1069-72. doi: 10.1017/S0022215115002182.
To compare the efficacy of two treatment regimens among Helicobacter pylori stool antigen positive children suffering from resistant otitis media with effusion.
The study comprised 258 children with bilateral otitis media with effusion; 134 were positive for H pylori stool antigen, and were equally and randomly allocated to the control group or study group. The control group received standard otitis media with effusion therapy (amoxicillin and clavulanate), while the study group received standard H pylori triple therapy (clarithromycin, metronidazole and lansoprazole).
In the control group, there was a marked clinical response to treatment in 33 of the 67 children (49.3 per cent). In the study group, there was a marked response in a significantly higher number of children (46 out of 67, 68.7 per cent). The 124 H pylori stool antigen negative children not included in the 2 aforementioned groups received amoxicillin and clavulanate, and a marked response in symptoms was evident in 98 of these children (79 per cent).
H pylori infection may lead to resistance to traditional otitis media with effusion treatment in some cases. H pylori eradication is associated with a high cure rate.
比较两种治疗方案对幽门螺杆菌粪便抗原阳性的难治性分泌性中耳炎患儿的疗效。
该研究纳入了258例双侧分泌性中耳炎患儿；其中134例幽门螺杆菌粪便抗原呈阳性，被平均随机分配至对照组或研究组。对照组接受标准的分泌性中耳炎治疗（阿莫西林和克拉维酸盐），而研究组接受标准的幽门螺杆菌三联疗法（克拉霉素、甲硝唑和兰索拉唑）。
对照组67例患儿中有33例（49.3%）治疗后有明显临床反应。研究组中，有明显反应的患儿数量显著更多（67例中有46例，68.7%）。上述两组未纳入的124例幽门螺杆菌粪便抗原阴性患儿接受了阿莫西林和克拉维酸盐治疗，其中98例（79%）患儿症状有明显改善。
幽门螺杆菌感染在某些情况下可能导致对传统分泌性中耳炎治疗产生耐药。根除幽门螺杆菌与高治愈率相关。
