幽门螺杆菌抗体与耳鼻喉科疾病的关系。
Association between Helicobacter pylori antibodies and otolaryngological diseases.
机构信息
The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Department of Otolaryngology Head and Neck Surgery, Chengdu, Sichuan, China; The Affiliated Hospital of North Sichuan Medical College, Department of Otolaryngology Head and Neck Surgery, Nanchong, Sichuan, China.
China West Normal University, Nanchong, Sichuan, China.
出版信息
Braz J Otorhinolaryngol. 2024 Nov-Dec;90(6):101488. doi: 10.1016/j.bjorl.2024.101488. Epub 2024 Aug 8.
OBJECTIVE
Observational studies have shown that Helicobacter pylori is related to some otolaryngological diseases. However, it is unclear if H. pylori infection causally affects these diseases. To elucidate H. pylori role in 12 common otolaryngological diseases, we conducted two-sample Mendelian randomization analysis.
METHODS
Single-nucleotide polymorphisms associated with 7 H. pylori antibodies (IgG, CagA, Catalase, GroEL, OMP, UREA and Vac A) served as instrumental variables. We primarily employed random-effects inverse variance weighting for causal estimation, supplemented by MR Egger, weighted median, simple mode, and weighted mode. Sensitivity analyses, including heterogeneity, pleiotropy, and leave-one-out tests, validated robustness.
RESULTS
MR analysis using inverse variance weighting (random effects) revealed genetically predicted H. pylori CagA antibodies correlated with increased risk of nonsuppurative otitis media (OR = 1.0778, 95% CI 1.0114-1.1487, p-value = 0.021). No causal relationship was observed between H. pylori antibodies and other common otolaryngological diseases. Sensitivity analyses found no pleiotropy or heterogeneity, affirming result reliability.
CONCLUSION
This study suggests that the levels of H. pylori CagA antibodies may contribute to the development of nonsuppurative otitis media. Further studies are needed in the future to elucidate the specific mechanism of H. pylori in this disease.
LEVEL OF EVIDENCE
Level III.
目的
观察性研究表明，幽门螺杆菌与一些耳鼻喉科疾病有关。然而，尚不清楚幽门螺杆菌感染是否会导致这些疾病。为了阐明幽门螺杆菌在 12 种常见耳鼻喉科疾病中的作用，我们进行了两样本 Mendelian 随机化分析。
方法
与 7 种幽门螺杆菌抗体（IgG、CagA、过氧化氢酶、GroEL、OMP、UREA 和 VacA）相关的单核苷酸多态性作为工具变量。我们主要采用随机效应逆方差加权法进行因果估计，同时补充了 MR Egger、加权中位数、简单模式和加权模式。敏感性分析，包括异质性、多效性和逐一排除测试，验证了结果的稳健性。
结果
使用逆方差加权（随机效应）的 MR 分析显示，遗传预测的幽门螺杆菌 CagA 抗体与非化脓性中耳炎的风险增加相关（OR=1.0778，95%CI 1.0114-1.1487，p 值=0.021）。未观察到幽门螺杆菌抗体与其他常见耳鼻喉科疾病之间存在因果关系。敏感性分析未发现多效性或异质性，证实了结果的可靠性。
结论
本研究表明，幽门螺杆菌 CagA 抗体的水平可能导致非化脓性中耳炎的发生。未来需要进一步的研究来阐明幽门螺杆菌在这种疾病中的具体机制。
证据水平
III 级。
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