Possible Role of in Ear Nose and Throat Diseases.

BACKGROUND

is assumed to cause many gastric and extragastric diseases. We aimed to assess the possible association role of in Otitis media with effusion (OME), nasal polyps and adenotonsillitis.

PATIENTS AND METHODS

A total of 186 patients with various ear, nose and throat diseases were included. The study comprised 78 children with chronic adenotonsillitis, 43 children with nasal polyps and 65 children with OME. OME patients were assigned to two subgroups: those who have and those who did not have adenoid hyperplasia. Among the patients with bilateral nasal polyps, 20 individuals had recurrent nasal polyps and 23 had de novo nasal polyps. Patients who have chronic adenotonsillitis were divided into three groups: those with chronic tonsillitis and those who underwent tonsillitis, those with chronic adenoiditis and adenoidectomy was performed, and those with chronic adenotonsillitis and underwent adenotonsillectomy. In addition to examination of antigen in stool samples of all included patients, real-time polymerase chain reaction (RT-PCR) for detection of in the effusion fluid was performed, additionally, Giemsa stain was used for detection of organism within the tissue samples when available.

RESULTS

Frequency of in effusion fluid was 28.6% in patients with OME and adenoid hyperplasia, while in those with OME it was only 17.4% with a p value of 0.2. Nasal polyp biopsies were positive in 13% patients of denovo, and 30% patients with recurrent nasal polyps, p=0.2. De novo nasal polyps were more prevalent in the positive stools than recurrent ones, p=0.7. All adenoid samples were negative for , only two samples of tonsillar tissue (8.3%) were positive for , and stool analysis was positive in 23 patients with chronic adenotonsillitis.

CONCLUSION

Lack of association between and occurrence of OME, nasal polyposis or recurrent adenotonsillitis.