Aref Zaki F, Bazeed Shamardan Ezzeldin Sayed, Nafady Asmaa, Fahim Dalia Fahim Mohammed, Ghweil Ali A, Sayed Mennatallah Ali Abdelrhman, Qubaisy Heba Mohammad, Khalefa Mahmoud, Arafa Usama A, Badawy Badawy Shahat, Abdelmohsen Ahmed Shawkat, Hassan Mohammed H, Abdelmaksoud Aida A
Department of ENT, Faculty of Medicine, South Valley University, Qena, Egypt.
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, South Valley University, Qena, Egypt.
Infect Drug Resist. 2023 Jun 2;16:3497-3509. doi: 10.2147/IDR.S411867. eCollection 2023.
is assumed to cause many gastric and extragastric diseases. We aimed to assess the possible association role of in Otitis media with effusion (OME), nasal polyps and adenotonsillitis.
A total of 186 patients with various ear, nose and throat diseases were included. The study comprised 78 children with chronic adenotonsillitis, 43 children with nasal polyps and 65 children with OME. OME patients were assigned to two subgroups: those who have and those who did not have adenoid hyperplasia. Among the patients with bilateral nasal polyps, 20 individuals had recurrent nasal polyps and 23 had de novo nasal polyps. Patients who have chronic adenotonsillitis were divided into three groups: those with chronic tonsillitis and those who underwent tonsillitis, those with chronic adenoiditis and adenoidectomy was performed, and those with chronic adenotonsillitis and underwent adenotonsillectomy. In addition to examination of antigen in stool samples of all included patients, real-time polymerase chain reaction (RT-PCR) for detection of in the effusion fluid was performed, additionally, Giemsa stain was used for detection of organism within the tissue samples when available.
Frequency of in effusion fluid was 28.6% in patients with OME and adenoid hyperplasia, while in those with OME it was only 17.4% with a p value of 0.2. Nasal polyp biopsies were positive in 13% patients of denovo, and 30% patients with recurrent nasal polyps, p=0.2. De novo nasal polyps were more prevalent in the positive stools than recurrent ones, p=0.7. All adenoid samples were negative for , only two samples of tonsillar tissue (8.3%) were positive for , and stool analysis was positive in 23 patients with chronic adenotonsillitis.
Lack of association between and occurrence of OME, nasal polyposis or recurrent adenotonsillitis.
被认为会引发许多胃部和胃外疾病。我们旨在评估其在分泌性中耳炎（OME）、鼻息肉和腺样体扁桃体炎中可能的关联作用。
共纳入186例患有各种耳鼻喉疾病的患者。该研究包括78例患有慢性腺样体扁桃体炎的儿童、43例患有鼻息肉的儿童和65例患有OME的儿童。OME患者被分为两个亚组：有腺样体增生的患者和没有腺样体增生的患者。在双侧鼻息肉患者中，20例为复发性鼻息肉，23例为初发性鼻息肉。患有慢性腺样体扁桃体炎的患者被分为三组：患有慢性扁桃体炎且接受扁桃体炎治疗的患者、患有慢性腺样体炎且接受腺样体切除术的患者、患有慢性腺样体扁桃体炎且接受腺样体扁桃体切除术的患者。除了检测所有纳入患者粪便样本中的抗原外，还对积液进行实时聚合酶链反应（RT-PCR）以检测，此外，如有可用的组织样本，吉姆萨染色用于检测组织样本中的生物体。
OME和腺样体增生患者积液中的检出率为28.6%，而OME患者中仅为17.4%，p值为0.2。初发性鼻息肉患者的鼻息肉活检阳性率为13%，复发性鼻息肉患者为30%，p = 0.2。初发性鼻息肉在粪便阳性患者中比复发性鼻息肉更常见，p = 0.7。所有腺样体样本检测均为阴性，仅两个扁桃体组织样本（8.3%）检测为阳性，23例慢性腺样体扁桃体炎患者的粪便分析呈阳性。
与OME、鼻息肉病或复发性腺样体扁桃体炎的发生之间缺乏关联。
