Shaikh Muhammad Shariq, Kayani Naila
Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi-74800.
J Coll Physicians Surg Pak. 2015 Oct;25 Suppl 2:S122-3. doi: 10.2015/JCPSP.S122S123.
Myeloid sarcoma is a solid collection of leukemic blast cells outside bone marrow. It is seen infrequently in association with overt Acute Myeloid Leukemia (AML), however, it invariably transforms into this aggressive condition. A28-year woman presented with a lump in left breast for last 2 years. Morphological and immunophenotypic results of breast mass were consistent with myeloid sarcoma. Bone marrow aspirate and biopsy were normal, however, patient died after one and a half years of diagnosis. Myeloid sarcoma at any extramedullary site heralds development of overt acute myeloid leukemia and should be appropriately managed at the time of diagnosis.
髓系肉瘤是骨髓外白血病原始细胞的实体性聚集。它很少与明显的急性髓系白血病（AML）相关联出现，然而，它总是会转变为这种侵袭性疾病。一名28岁女性在过去两年中左乳出现肿块。乳房肿块的形态学和免疫表型结果与髓系肉瘤一致。骨髓穿刺和活检结果正常，然而，患者在诊断后一年半死亡。任何髓外部位的髓系肉瘤都预示着明显急性髓系白血病的发展，在诊断时应进行适当处理。
