Guiran Zhao, Ying Wang, Guijun Wang, Chengyue Wang, Yusheng Yao
Cleft Palate Craniofac J. 2017 Mar;54(2):193-201. doi: 10.1597/15-044. Epub 2015 Nov 2.
The purpose of this study was to evaluate the administration of recombinant human bone morphogenetic protein-2 (rhBMP-2) on trans-sutural distraction osteogenesis (TSDO) of the transverse palatal suture in growing dogs.
A total of 36 growing dogs were used in this study. The experimental animals were treated with different elastic force and rhBMP-2. The bone regeneration was determined with X-ray, histology, and clinical evaluation. The computed values underwent statistical analyses using analysis of variance.
The maxillary complex was most noticeably advanced with an applied elastic force of 600 g (22.4 ± 5.0 mm) and 800 g + rhBMP-2 (24 ± 5.1 mm). Immunohistochemical staining showed that the expression of bone morphogenetic protein-2 and bone morphogenetic protein-4 varied with different elastic force. These changes were statistically significant when 600 g and 800 g + rhBMP-2 were applied within 2 weeks of distraction when compared with controls (P < .05).
The results of this study suggest that TSDO in the growing dog should be safe and well tolerated when inducing bony lengthening of the maxilla. rhBMP-2 plays an important role in bone regeneration using TSDO.
