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在288例埃博拉病毒病患者中，年龄和埃博拉病毒载量与死亡率及生存时间相关。

Age and Ebola viral load correlate with mortality and survival time in 288 Ebola virus disease patients.

作者信息

Li Jin, Duan Hui-Juan, Chen Hao-Yang, Ji Ying-Jie, Zhang Xin, Rong Yi-Hui, Xu Zhe, Sun Li-Jian, Zhang Ji-Yuan, Liu Li-Ming, Jin Bo, Zhang Jian, Du Ning, Su Hai-Bin, Teng Guang-Ju, Yuan Yue, Qin En-Qiang, Jia Hong-Jun, Wang Shu, Guo Tong-Sheng, Wang Ye, Mu Jin-Song, Yan Tao, Li Zhi-Wei, Dong Zheng, Nie Wei-Min, Jiang Tian-Jun, Li Chen, Gao Xu-Dong, Ji Dong, Zhuang Ying-Jie, Li Lei, Wang Li-Fu, Li Wen-Gang, Duan Xue-Zhang, Lu Yin-Ying, Sun Zhi-Qiang, Kanu Alex B J, Koroma Sheku M, Zhao Min, Ji Jun-Sheng, Wang Fu-Sheng

机构信息

Beijing 302 Hospital, Beijing, 100039, China.

Jui Government Hospital (Sierra Leone -China Friendship Hospital), Kossoh Town, Western Area Rural District, Sierra Leone.

出版信息

Int J Infect Dis. 2016 Jan;42:34-39. doi: 10.1016/j.ijid.2015.10.021. Epub 2015 Oct 30.

DOI:10.1016/j.ijid.2015.10.021
PMID:26523640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7110900/
Abstract

BACKGROUND

A Chinese medical team managed Ebola virus disease (EVD) patients in Sierra Leone from October 2014 to March 2015 and attended to 693 suspected patients, of whom 288 had confirmed disease.

METHODS

A retrospective study was conducted of the 288 patients with confirmed disease. Clinical symptoms, manifestations, and serum viral load were analyzed and compared among the different groups for mortality and survival time.

RESULTS

Among the 288 confirmed EVD patients (149 male and 139 female, median age 28 years, and median log viral load 6.68), 98 died, 36 recovered, and 154 were lost to follow-up. Common symptoms were fever (77.78%), fatigue (64.93%), abdominal pain (64.58%), headache (62.85%), and diarrhea (61.81%). Compared to patients aged<18 years, those who were older than 40 years had a higher probability of death (odds ratio 2.855, p=0.044). Patients with a viral load of >10(6) copies/ml had a higher case fatality rate than those with <10(6) copies/ml (odds ratio 3.095, p=0.004). Cox regression showed that age, viral load, and the presence of diarrhea correlated with mortality.

CONCLUSION

Patients with a high viral load, of older age, and with diarrhea had a higher mortality and shorter survival time.

摘要

背景

2014年10月至2015年3月，一支中国医疗队在塞拉利昂管理埃博拉病毒病（EVD）患者，并诊治了693名疑似患者，其中288人确诊患病。

方法

对288例确诊患者进行回顾性研究。分析比较不同组患者的临床症状、表现及血清病毒载量与死亡率和生存时间的关系。

结果

在288例确诊的EVD患者中（男性149例，女性139例，中位年龄28岁，中位病毒载量对数为6.68），98例死亡，36例康复，154例失访。常见症状有发热（77.78%）、乏力（64.93%）、腹痛（64.58%）、头痛（62.85%）和腹泻（61.81%）。与年龄<18岁的患者相比，年龄大于40岁的患者死亡概率更高（比值比2.855，p = 0.044）。病毒载量>10(6)拷贝/ml的患者病死率高于病毒载量<10(6)拷贝/ml的患者（比值比3.095，p = 0.004）。Cox回归分析显示，年龄、病毒载量和腹泻与死亡率相关。

结论

病毒载量高、年龄较大且伴有腹泻的患者死亡率更高，生存时间更短。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/66e0a1e8e1a7/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/48127c415ee6/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/c107c6682725/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/6f4f976006a0/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/c5f0c375644e/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/433eff2cd06c/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/66e0a1e8e1a7/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/48127c415ee6/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/c107c6682725/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/6f4f976006a0/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/c5f0c375644e/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/433eff2cd06c/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/7110900/66e0a1e8e1a7/gr6_lrg.jpg

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