Papageorgiou Spyridon N, Kloukos Dimitrios, Petridis Haralampos, Pandis Nikolaos
Int J Prosthodont. 2015 Nov-Dec;28(6):586-93. doi: 10.11607/ijp.4357.
The objective of this study was to assess the risk of bias of randomized controlled trials (RCTs) published in prosthodontic and implant dentistry journals.
The last 30 issues of 9 journals in the field of prosthodontic and implant dentistry (Clinical Implant Dentistry and Related Research, Clinical Oral Implants Research, Implant Dentistry, International Journal of Oral & Maxillofacial Implants, International Journal of Periodontics and Restorative Dentistry, International Journal of Prosthodontics, Journal of Dentistry, Journal of Oral Rehabilitation, and Journal of Prosthetic Dentistry) were hand-searched for RCTs. Risk of bias was assessed using the Cochrane Collaboration's risk of bias tool and analyzed descriptively.
From the 3,667 articles screened, a total of 147 RCTs were identified and included. The number of published RCTs increased with time. The overall distribution of a high risk of bias assessment varied across the domains of the Cochrane risk of bias tool: 8% for random sequence generation, 18% for allocation concealment, 41% for masking, 47% for blinding of outcome assessment, 7% for incomplete outcome data, 12% for selective reporting, and 41% for other biases.
The distribution of high risk of bias for RCTs published in the selected prosthodontic and implant dentistry journals varied among journals and ranged from 8% to 47%, which can be considered as substantial.
本研究的目的是评估发表在口腔修复学和种植牙科学期刊上的随机对照试验（RCT）的偏倚风险。
手工检索口腔修复学和种植牙科学领域9种期刊（《临床种植牙学及相关研究》《临床口腔种植研究》《种植牙学》《国际口腔颌面种植杂志》《国际牙周病与修复牙科学杂志》《国际口腔修复学杂志》《牙科学杂志》《口腔修复学杂志》和《口腔修复体学杂志》）的最近30期，以查找随机对照试验。使用Cochrane协作网的偏倚风险工具评估偏倚风险，并进行描述性分析。
在筛选的3667篇文章中，共识别并纳入了147项随机对照试验。发表的随机对照试验数量随时间增加。偏倚风险评估为高风险的总体分布在Cochrane偏倚风险工具的各个领域有所不同：随机序列生成方面为8%，分配隐藏方面为18%，盲法方面为41%，结局评估盲法方面为47%，不完整结局数据方面为7%，选择性报告方面为12%，其他偏倚方面为41%。
在所选口腔修复学和种植牙科学期刊上发表的随机对照试验中，高偏倚风险的分布在不同期刊之间有所不同，范围从8%到47%，可认为是相当大的。
