利用显微解剖技术检测马拉硫磷杂质对肾脏的损害。

Detection of kidney damage by malathion impurities using a microdissection technique.

作者信息

Keadtisuke S, Dheranetra W, Fukuto T R

机构信息

Department of Entomology, University of California, Riverside 92521.

出版信息

Toxicol Lett. 1989 Apr;47(1):53-9. doi: 10.1016/0378-4274(89)90085-4.

DOI:10.1016/0378-4274(89)90085-4

PMID:2652380

Abstract

O,O,S-Trimethylphosphorothioate (OOS-Me) and O,S,S-trimethylphosphorodithioate (OSS-Me) are impurities in technical grade malathion and related insecticides which have been shown to cause delayed death in rats following a single oral dose of 40-60 mg/kg. In connection with studies on the mode of action of these compounds, work on the microdissection and examination of nephrons was carried out. Nephrons from impurities-treated rats showed swelling, distortion and distension of glomeruli, as well as narrowing of the first part of the proximal tubule (swan neck). These results were similar to those observed from kidney tissue obtained from cadmium-chloride-treated rats and are indicative of OOS-Me and OSS-Me-induced kidney tubule damage.

摘要

O,O,S-三甲基硫代磷酸酯（OOS-Me）和O,S,S-三甲基二硫代磷酸酯（OSS-Me）是工业级马拉硫磷及相关杀虫剂中的杂质，已证实大鼠单次口服剂量为40 - 60 mg/kg后会导致延迟死亡。在关于这些化合物作用方式的研究中，开展了肾单位的显微解剖和检查工作。来自用杂质处理过的大鼠的肾单位显示出肾小球肿胀、变形和扩张，以及近端小管起始部分（鹅颈）变窄。这些结果与从氯化镉处理过的大鼠获得的肾组织中观察到的结果相似，表明OOS-Me和OSS-Me会导致肾小管损伤。