一名小儿患者的低亚二倍体混合表型急性白血病
Mixed Phenotype Acute Leukemia with Low Hypodiploidy in a Pediatric Patient.
作者信息
Salazar Elizabeth G, Wertheim Gerald B, Biegel Jaclyn A, Hwang William, Tasian Sarah K, Rheingold Susan R
机构信息
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
出版信息
J Pediatr Oncol. 2015;3(1):24-28. doi: 10.14205/2309-3021.2015.03.01.4. Epub 2015 Mar 25.
Abstract
We describe the case of a 16 year-old female with mixed phenotype acute leukemia B/myeloid, NOS (formerly biphenotypic leukemia) with masked hypodiploidy and somatic and deletions. She achieved morphologic remission with lymphoid-directed multi-agent chemotherapy, but experienced an early medullary relapse 11 months from initial diagnosis. Her case details the unusual finding of hypodiploidy in a patient with ambiguous lineage leukemia and highlights the complexity of therapy selection for these high-risk patients.
摘要
我们描述了一名16岁女性混合表型急性白血病B/髓系（未另行分类，原双表型白血病）患者的病例，该患者存在隐匿性亚二倍体以及体细胞突变和缺失。她通过淋巴细胞导向的多药化疗实现了形态学缓解，但在初次诊断后11个月出现早期髓系复发。她的病例详细介绍了在谱系不明确的白血病患者中发现的不寻常的亚二倍体情况，并突出了这些高危患者治疗选择的复杂性。
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