Tallents S, Forster D C, Garson O M, Michael P M, Briggs P, Brodie G N, Pilkington G, Januszewicz E
Department of Haematology, Prince Henry's Hospital, Melbourne, Victoria.
Pathology. 1987 Apr;19(2):197-200. doi: 10.3109/00313028709077134.
A patient diagnosed as having acute lymphoblastic leukemia (L2) relapsed 4 months later and was found to have morphologic and immunologic evidence of a biphenotypic hybrid acute leukemia. Chromosome analysis at relapse showed two abnormal clones, one with marked hypodiploidy and the other with exactly double the hypodiploid clone. It is considered that this is an example of a hybrid lymphoblastic/nonlymphoblastic leukemia with unique karyotype.
一名被诊断为急性淋巴细胞白血病(L2型)的患者在4个月后复发,发现有双表型混合急性白血病的形态学和免疫学证据。复发时的染色体分析显示有两个异常克隆,一个具有明显的亚二倍体,另一个是亚二倍体克隆的两倍。认为这是具有独特核型的混合淋巴细胞/非淋巴细胞白血病的一个例子。