Nishikawa Hirokazu, Shirano Michinori, Kasamatsu Yu, Morimura Ayumi, Iida Ko, Kishi Tomomi, Goto Tetsushi, Okamoto Saki, Ehara Eiji
Department of Clinical Laboratory, Osaka City General Hospital, 2-13-22, Miyakojimahondoori, Miyakojima-ku, Osaka-shi, Osaka, 534-0021, Japan.
Department of Infectious Diseases, Osaka City General Hospital, 2-13-22, Miyakojimahondoori, Miyakojima-ku, Osaka-shi, Osaka, 534-0021, Japan.
Diagn Microbiol Infect Dis. 2016 Jan;84(1):69-73. doi: 10.1016/j.diagmicrobio.2015.09.015. Epub 2015 Sep 26.
To assess relationships of inflammatory markers and 2 related clinical factors with blood culture results, we retrospectively investigated inpatients' blood culture and blood chemistry findings that were recorded from January to December 2014 using electronic medical records and analyzed the data of 852 subjects (426 culture-positive and 426 culture-negative). Results suggested that the risk of positive blood culture statistically increased as inflammatory marker levels and the number of related factors increased. Concerning the effectiveness of inflammatory markers, when the outcome definition was also changed for C-reactive protein (CRP), the odds ratio had a similar value, whereas when the outcome definition of blood culture positivity was used for procalcitonin (PCT), the greatest effectiveness of that was detected. Therefore, the current results suggest that PCT is more useful than CRP as an auxiliary indication of bacterial infection.
为评估炎症标志物及两个相关临床因素与血培养结果之间的关系，我们回顾性调查了2014年1月至12月使用电子病历记录的住院患者的血培养和血液化学检查结果，并分析了852名受试者（426名培养阳性和426名培养阴性）的数据。结果表明，随着炎症标志物水平和相关因素数量的增加，血培养阳性的风险在统计学上显著增加。关于炎症标志物的有效性，当对C反应蛋白（CRP）的结果定义也进行改变时，优势比具有相似的值，而当将血培养阳性的结果定义用于降钙素原（PCT）时，检测到其最大有效性。因此，目前的结果表明，作为细菌感染的辅助指标，PCT比CRP更有用。
