Yu Wei, Le Hai-Wei, Lu Yi-Gao, Hu Jun-An, Yu Jian-Bo, Wang Ming, Shen Wei
Department of Neurosurgery, The People's Hospital of Beilun District, Beilun Branch Hospital of The First Affiliated Hospital of Medical School of Zhejiang University, 1288 Lushan East Road, Beilun District, Ningbo 315800, China.
Department o f Neurosurgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China.
Clin Chim Acta. 2015 Dec 7;451(Pt B):111-6. doi: 10.1016/j.cca.2015.10.017. Epub 2015 Oct 23.
Mannose-binding lectin (MBL) is a key component of innate immunity. The expression of cortical MBL is up-regulated after clinical and experimental head trauma. This study aimed to assess the association of serum MBL levels with injury severity and long-term clinical outcomes after severe traumatic brain injury (STBI).
Serum MBL levels were measured in 122 patients and 100 healthy controls. Multivariate analyses were used to analyze the relationship between serum MBL levels and trauma severity reflected by Glasgow Coma Scale scores as well as between serum MBL levels and 6-month mortality and unfavorable outcome (Glasgow Outcome Scale score: 1-3). A receiver operating characteristic (ROC) curve was structured to evaluate the prognostic predictive performance of serum MBL levels.
Compared with healthy controls, serum MBL levels of patients were markedly elevated. Using multivariate analyses, serum MBL levels were found to be associated closely with Glasgow Coma Scale (GCS) scores and MBL emerged as an independent predictor for 6-month mortality and unfavorable outcome. Under ROC curve, serum MBL levels and GCS scores possessed similar prognostic predictive values.
Increased serum level of MBL was independently associated with head trauma severity and long-term clinical outcomes of STBI.
甘露糖结合凝集素（MBL）是固有免疫的关键组成部分。临床和实验性头部创伤后，皮质MBL的表达上调。本研究旨在评估严重创伤性脑损伤（STBI）后血清MBL水平与损伤严重程度及长期临床结局的相关性。
测定了122例患者和100例健康对照者的血清MBL水平。采用多因素分析来分析血清MBL水平与格拉斯哥昏迷量表评分所反映的创伤严重程度之间的关系，以及血清MBL水平与6个月死亡率和不良结局（格拉斯哥结局量表评分：1 - 3）之间的关系。构建了受试者工作特征（ROC）曲线以评估血清MBL水平的预后预测性能。
与健康对照者相比，患者的血清MBL水平显著升高。通过多因素分析发现，血清MBL水平与格拉斯哥昏迷量表（GCS）评分密切相关，并且MBL是6个月死亡率和不良结局的独立预测因子。在ROC曲线下，血清MBL水平和GCS评分具有相似的预后预测价值。
血清MBL水平升高与STBI的头部创伤严重程度和长期临床结局独立相关。
