早孕期母体腹部肥胖预测妊娠中期糖代谢异常和妊娠期糖尿病。
First-Trimester Maternal Abdominal Adiposity Predicts Dysglycemia and Gestational Diabetes Mellitus in Midpregnancy.
机构信息
Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, ON, Canada Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, ON, Canada Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.
出版信息
Diabetes Care. 2016 Jan;39(1):61-4. doi: 10.2337/dc15-2027. Epub 2015 Nov 2.
OBJECTIVE
This study assessed the association between first-trimester abdominal adiposity and dysglycemia and gestational diabetes mellitus (GDM) in midpregnancy.
RESEARCH DESIGN AND METHODS
In a prospective cohort of 485 women, we measured subcutaneous (SAT), visceral (VAT), and total (TAT) adipose tissue depth, using ultrasound at 11-14 weeks' gestation. Logistic regression analysis assessed the relation between quartiles of SAT, VAT, or TAT depth and the composite outcome of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or GDM, based on a 75-g oral glucose tolerance test at 24-28 weeks.
RESULTS
Adjusting for maternal age, ethnicity, family history of diabetes, and BMI, quartile 4 versus quartile 1 VAT (adjusted odds ratio [aOR] 3.1, 95% CI 1.1-9.5) and TAT (aOR 2.7, 95% CI 1.1-7.8) were significantly associated with the composite outcome, but SAT was not (aOR 1.8, 95% CI 0.70-4.8). The same was seen for GDM alone.
CONCLUSIONS
Elevated first-trimester VAT and TAT depth independently predicted the risk of dysglycemia later in pregnancy.
目的
本研究旨在评估孕早期腹部肥胖与糖代谢异常和妊娠中期糖尿病（GDM）之间的关联。
研究设计和方法
在一项前瞻性队列研究中，我们在 11-14 周妊娠时使用超声测量了皮下（SAT）、内脏（VAT）和总（TAT）脂肪组织深度。基于 24-28 周 75g 口服葡萄糖耐量试验，logistic 回归分析评估了 SAT、VAT 或 TAT 深度四分位数与空腹血糖受损（IFG）、糖耐量受损（IGT）或 GDM 复合结局之间的关系。
结果
调整了母亲年龄、种族、糖尿病家族史和 BMI 后，VAT（调整后的优势比[aOR]3.1，95%可信区间[CI]1.1-9.5）和 TAT（aOR 2.7，95% CI 1.1-7.8）四分位数 4 与复合结局显著相关，但 SAT 无显著相关性（aOR 1.8，95% CI 0.70-4.8）。同样的情况也适用于 GDM 单独的情况。
结论
孕早期 VAT 和 TAT 深度升高独立预测了妊娠后期糖代谢异常的风险。
Zotero 插件