Salmen Bianca-Margareta, Pietrosel Valeria-Anca, Durdu Cristiana-Elena, Salmen Teodor, Diaconu Cosmina Theodora, Bica Ioana-Cristina, Potcovaru Claudia Gabriela, Gherghiceanu Florentina, Stoica Roxana-Adriana, Pantea Stoian Anca
Doctoral School, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Diabetes, Nutrition and Metabolic Diseases, "Prof. Dr N.C.Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, 030167 Bucharest, Romania.
Biomedicines. 2023 May 22;11(5):1492. doi: 10.3390/biomedicines11051492.
The increasing prevalence of gestational diabetes mellitus (GDM) requires non-invasive and precise techniques for evaluating the predisposing risk factors such as visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). According to PRISMA, we developed a systematic review and searched after "visceral adipose tissue AND gestational diabetes" and identified 221 articles on the MEDLINE and Word of Science databases. After assessing them for inclusion criteria and two researchers screened them, 11 relevant articles were included. Although evidence is conflicting, more studies favor using US-determined VAT in GDM prediction. VAT may be more valuable than body mass index or SAT in predicting GDM. VAT can represent an additive factor to the prediction tool of the risk of developing GDM when used in conjunction with other anthropometric or biological parameters or maternal risk factors. US measurements are heterogeneous given different evaluation techniques, cut-off values and inter-operator variation. A significant limitation is the lack of a gold standard to identify GDM confidently. Pregnant women may benefit from early monitoring and preventive care if classified as high risk for GDM early in the gestational period. US-measured VAT during the first trimester of pregnancy seems a valuable and inexpensive screening approach to predict GDM development later in pregnancy, either by itself or if used in conjunction with other clinical and biological parameters.
妊娠期糖尿病（GDM）患病率的不断上升，需要采用非侵入性且精确的技术来评估诸如内脏脂肪组织（VAT）和皮下脂肪组织（SAT）等易感风险因素。根据系统评价和Meta分析的首选报告项目（PRISMA），我们开展了一项系统评价，在检索了“内脏脂肪组织与妊娠期糖尿病”后，在MEDLINE和科学网数据库中识别出221篇文章。在根据纳入标准对这些文章进行评估并由两名研究人员进行筛选后，纳入了11篇相关文章。尽管证据相互矛盾，但更多研究倾向于使用超声测定的内脏脂肪组织来预测妊娠期糖尿病。在内脏脂肪组织在预测妊娠期糖尿病方面可能比体重指数或皮下脂肪组织更有价值。当与其他人体测量学或生物学参数或母体风险因素结合使用时，内脏脂肪组织可以作为预测妊娠期糖尿病发生风险的工具的一个附加因素。鉴于不同的评估技术、临界值和操作者间差异，超声测量结果存在异质性。一个显著的局限性是缺乏能可靠识别妊娠期糖尿病的金标准。如果在妊娠期早期被归类为妊娠期糖尿病高危孕妇，可能会从早期监测和预防性护理中受益。妊娠早期通过超声测量的内脏脂肪组织似乎是一种有价值且成本低廉的筛查方法，可单独或与其他临床和生物学参数结合使用，来预测妊娠后期妊娠期糖尿病的发生。
