Islam Saleem, McLaughlin Jillian, Pierson Justine, Jolley Christopher, Kedar Archana, Abell Thomas
Division of Pediatric Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States.
Division of Pediatric Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States.
J Pediatr Surg. 2016 Jan;51(1):67-71. doi: 10.1016/j.jpedsurg.2015.10.015. Epub 2015 Oct 23.
Gastric electrical stimulation (GES) has been used in adults with gastroparesis. However its use has been limited in children. We describe the largest experience with GES in children with long-term outcomes.
Data were collected on children who underwent GES over a 10-year period. Data regarding demographics, medical history, hospital course, and outcomes were collected and analyzed. Symptom scores (validated Likert scores) were compared using a paired Student's t test.
Overall, 97 patients underwent GES, and a majority were teenage Caucasian girls. Ninety-six had temporary GES (tGES), and 66 had improvement in their symptoms. A total of 67 underwent permanent implantation (pGES), and there was significant reduction in all individual symptoms (p<0.001) as well as the total symptom score (TSS) (p<0.0001) at 1, 6, 12, and >12 months. Recurrence of symptoms leading to device removal occurred in 7 cases. Forty-one patients had continued improvement in symptoms for over 12 months, with a mean follow-up of 3.5 years (range 1-9 years).
This study represents the largest experience of systematic application of GES in children. GES is a safe and effective therapy for selected children with intractable GP with continued symptomatic improvement at 1 year and beyond.
胃电刺激（GES）已用于患有胃轻瘫的成人。然而，其在儿童中的应用一直有限。我们描述了在儿童中应用GES的最大规模经验及长期结果。
收集了在10年期间接受GES治疗的儿童的数据。收集并分析了有关人口统计学、病史、住院过程及结果的数据。使用配对学生t检验比较症状评分（经过验证的李克特评分）。
总体而言，97例患者接受了GES治疗，大多数是十几岁的白人女孩。96例接受了临时性胃电刺激（tGES），其中66例症状有所改善。共有67例接受了永久性植入（pGES），在1、6、12和超过12个月时，所有个体症状（p<0.001）以及总症状评分（TSS）（p<0.0001）均有显著降低。7例因症状复发导致设备移除。41例患者症状持续改善超过12个月，平均随访3.5年（范围1 - 9年）。
本研究代表了在儿童中系统应用GES的最大规模经验。GES对于选定的难治性胃轻瘫儿童是一种安全有效的治疗方法，在1年及以后症状持续改善。
