He Zhi-Yao, Shi Kun, Wei Yu-Quan, Qian Zhi-Yong
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China.
Curr Drug Metab. 2016;17(2):168-86. doi: 10.2174/1389200216666151103115944.
Poly(ether-ether) and poly(ether-ester) block copolymers have been widely applied in biomedical fields over two decades due to their good safety and biocompatibility. Poly(ethylene glycol), poly(ethylene glycol)-poly(propylene glycol) and poly(lactic-co-glycolic acid) have been approved as excipients by Food and Drug Administration. Because of the broad perspective in biomedical fields, many novel poly(etherether) and poly(ether-ester) block copolymers have been developed for drug delivery, gene therapy and tissue engineering in recent years. This review focuses on active targeting theranostic systems, gene delivery systems and tissue engineering based on poly(ether-ether) and poly(ether-ester) block copolymers.
We perform a structured search of bibliographic databases for peer-reviewed scientific reports using a focused review question and inclusion/exclusion criteria. The literatures related to the topics of this review are cataloged according to the developed copolymers or their applications such as active targeting theranostic systems, gene delivery systems and tissue engineering. Some important advances and new trends are summarized in this review.
Some commercial poly(ether-ether) copolymers have been used as excipients for drug research and development. Amphiphilic and biodegradable poly(ether-ester) diblock copolymers are capable of formulating biomedical nanoparticulate theranostic systems, and targeting moiety-functionalized poly(ether-ester) diblock copolymers will be further developed and applied in biomedical nanotechnology fields in the near future. Meanwhile, triblock or multiblock poly(ether-ether) and poly(ether-ester) copolymers with environmentsensitive properties are suitable for gene delivery and tissue engineering. Poly(ether-ether) and poly(ether-ester) copolymers are being extensively applied in active targeting theranostic systems, gene delivery systems and tissue engineering.
Biodegradable, environment-sensitive and targeting moiety-functionalized block copolymers, which are being applied in active targeting theranostic systems, gene delivery systems and tissue engineering, are promising candidates for treatment of various diseases.
聚（醚 - 醚）和聚（醚 - 酯）嵌段共聚物因其良好的安全性和生物相容性，在过去二十多年里已被广泛应用于生物医学领域。聚乙二醇、聚（乙二醇） - 聚（丙二醇）和聚（乳酸 - 乙醇酸共聚物）已被美国食品药品监督管理局批准为辅料。由于在生物医学领域具有广阔前景，近年来已开发出许多新型聚（醚 - 醚）和聚（醚 - 酯）嵌段共聚物用于药物递送、基因治疗和组织工程。本综述聚焦于基于聚（醚 - 醚）和聚（醚 - 酯）嵌段共聚物的主动靶向诊疗系统、基因递送系统和组织工程。
我们使用聚焦的综述问题和纳入/排除标准，对文献数据库进行结构化搜索，以获取同行评审的科学报告。与本综述主题相关的文献根据所开发的共聚物或其应用（如主动靶向诊疗系统、基因递送系统和组织工程）进行分类。本综述总结了一些重要进展和新趋势。
一些市售的聚（醚 - 醚）共聚物已被用作药物研发的辅料。两亲性和可生物降解的聚（醚 - 酯）二嵌段共聚物能够构建生物医学纳米颗粒诊疗系统，且靶向部分功能化的聚（醚 - 酯）二嵌段共聚物在不久的将来将得到进一步开发并应用于生物医学纳米技术领域。同时，具有环境敏感特性的三嵌段或多嵌段聚（醚 - 醚）和聚（醚 - 酯）共聚物适用于基因递送和组织工程。聚（醚 - 醚）和聚（醚 - 酯）共聚物正被广泛应用于主动靶向诊疗系统、基因递送系统和组织工程。
可生物降解、环境敏感且靶向部分功能化的嵌段共聚物正应用于主动靶向诊疗系统、基因递送系统和组织工程，是治疗各种疾病的有前景的候选材料。
