Yokota Megumi, Hirasawa Akira, Makita Kazuya, Akahane Tomoko, Sakai Kensuke, Makabe Takeshi, Horiba Yuko, Yamagami Wataru, Ogawa Mariko, Iwata Takashi, Yanamoto Shigehisa, Deshimaru Ryota, Banno Kouji, Susumu Nobuyuki, Aoki Daisuke
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Prz Menopauzalny. 2015 Sep;14(3):161-7. doi: 10.5114/pm.2015.54339. Epub 2015 Sep 30.
Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis. However, the relationship between osteoporosis and genetic polymorphisms in Japanese women treated with BSO is not well understood. To improve the quality of life for post-BSO patients, it is important to determine the genetic factors that influence their risk for osteoporosis. The aim of this study was to investigate the association between gene variations of estrogen metabolism-related genes and osteoporosis in surgically menopausal patients, which may improve their quality of life.
This study included 203 menopausal women treated with BSO because of gynecologic disorders. One hundred and twenty-six women with artificial (surgical) menopause, who had undergone BSO in the premenopausal period, were compared with 77 women with natural menopause, who had undergone BSO in the postmenopausal period. The women were tested for bone mineral density to diagnose osteoporosis. Polymorphisms of estrogen receptor 1 (ESR1) and UDP-glucuronosyl transferase (UGT) genes UGT2B17 and UGT1A1 were analyzed, and their association with bone mass and osteoporosis was statistically evaluated.
No significant association was found between osteoporosis and polymorphisms in ESR1, UGT2B17, or UGT1A1 in both groups, suggesting that BSO might be a more significant physiological factor in influencing bone mass density compared to genetic variations.
These results suggest that the ESR1, UGT2B17, and UGT1A1 polymorphisms are not genetic factors affecting osteoporosis in postmenopausal Japanese women.
双侧输卵管卵巢切除术（BSO）是骨质疏松症的一个危险因素。先前的研究报道了基因多态性与患骨质疏松症风险之间的关联。然而，对于接受BSO治疗的日本女性，骨质疏松症与基因多态性之间的关系尚不清楚。为了提高BSO术后患者的生活质量，确定影响其骨质疏松症风险的遗传因素很重要。本研究的目的是调查雌激素代谢相关基因的基因变异与手术绝经患者骨质疏松症之间的关联，这可能会改善她们的生活质量。
本研究纳入了203名因妇科疾病接受BSO治疗的绝经女性。将126名在绝经前期接受BSO的人工（手术）绝经女性与77名在绝经后期接受BSO的自然绝经女性进行比较。对这些女性进行骨密度检测以诊断骨质疏松症。分析雌激素受体1（ESR1）和UDP-葡萄糖醛酸基转移酶（UGT）基因UGT2B17和UGT1A1的多态性，并对它们与骨量和骨质疏松症的关联进行统计学评估。
两组中，ESR1、UGT2B17或UGT1A1的多态性与骨质疏松症之间均未发现显著关联，这表明与基因变异相比，BSO可能是影响骨密度的更重要生理因素。
这些结果表明，ESR1、UGT2B17和UGT1A1多态性不是影响绝经后日本女性骨质疏松症的遗传因素。
