*Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan.
Jpn J Clin Oncol. 2013 Nov;43(11):1087-92. doi: 10.1093/jjco/hyt125. Epub 2013 Sep 1.
Previous studies have reported an association between endometrial cancer and the risk of metabolic syndrome; however, the pattern of endometrial cancer-associated dyslipidemia is not well understood. The standard therapy for endometrial cancer is total abdominal hysterectomy and bilateral salpingo-oophorectomy. Premenopausal bilateral salpingo-oophorectomy may cause adverse events, including dyslipidemia. Gynecologists have to care dyslipidemia in endometrial cancer survivors at cancer follow-up clinic.
This study included 693 patients who had undergone bilateral salpingo-oophorectomy, and included 412 women with incident endometrial cancer and 281 controls. We divided the patients into two categories according to whether they had a premenopausal or postmenopausal bilateral oophorectomy. Serum lipid levels were measured and statistically analyzed.
Hypertriglyceridemia was statistically more frequent in patients who had undergone bilateral salpingo-oophorectomy both before and after menopause than in the corresponding non-endometrial cancer controls. High levels of low-density lipoprotein cholesterol and a high low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio were statistically more frequent in patients who had undergone bilateral salpingo-oophorectomy before menopause than in non-endometrial cancer controls.
Our report highlights the importance of the relationship between endometrial cancer and lipid metabolism, which may aid in preventing cerebrovascular or cardiovascular diseases due to dyslipidemia and improving the quality of life in endometrial cancer survivors.
先前的研究报告指出子宫内膜癌与代谢综合征风险之间存在关联，但子宫内膜癌相关血脂异常的模式尚不清楚。子宫内膜癌的标准治疗方法是全子宫切除术和双侧输卵管卵巢切除术。绝经前双侧输卵管卵巢切除术可能会导致不良事件，包括血脂异常。妇科医生在癌症随访诊所必须关注子宫内膜癌幸存者的血脂异常。
本研究纳入了 693 名接受过双侧输卵管卵巢切除术的患者，其中 412 名女性患有新发子宫内膜癌，281 名为对照。我们根据患者是否接受过绝经前或绝经后双侧卵巢切除术将患者分为两类。测量血清脂质水平并进行统计学分析。
与相应的非子宫内膜癌对照组相比，绝经前和绝经后均接受双侧输卵管卵巢切除术的患者，高甘油三酯血症更为常见。与非子宫内膜癌对照组相比，绝经前接受双侧输卵管卵巢切除术的患者，低密度脂蛋白胆固醇水平升高和低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值升高更为常见。
本报告强调了子宫内膜癌与脂代谢之间的关系的重要性，这可能有助于预防因血脂异常引起的脑血管或心血管疾病，并提高子宫内膜癌幸存者的生活质量。
