Alsharafi Walid A, Xiao Bo, Abuhamed Mutasem M, Luo Zhaohui
Department of Neurology, Xiangya Hospital, Central South University Changsha, China.
Department of Neurology, Alkhadamat Altebia Hospital Amman, Jordan.
Front Mol Neurosci. 2015 Oct 13;8:59. doi: 10.3389/fnmol.2015.00059. eCollection 2015.
Recently, microRNAs (miRNAs) are reported to be crucial modulators in the pathogenesis and potential treatment of epilepsies. To date, several miRNAs have been demonstrated to be significantly expressed in the epileptic tissues and strongly associated with the development of epilepsy. Specifically, miRNAs regulate synaptic strength, inflammation, neuronal and glial function, ion channels, and apoptosis. Furthermore, peripheral blood miRNAs can also be utilized as diagnostic biomarkers to assess disease risk and treatment responses. Here, we will summarize the recent available literature regarding the role of miRNAs in the pathogenesis and treatment of epilepsy. Moreover, we will provide brief insight into the potential of miRNA as diagnostic biomarkers for early diagnosis and prognosis of epilepsy.
最近，据报道微小RNA（miRNA）是癫痫发病机制和潜在治疗中的关键调节因子。迄今为止，已证明几种miRNA在癫痫组织中显著表达，并与癫痫的发展密切相关。具体而言，miRNA调节突触强度、炎症、神经元和神经胶质细胞功能、离子通道以及细胞凋亡。此外，外周血miRNA也可作为诊断生物标志物，用于评估疾病风险和治疗反应。在此，我们将总结关于miRNA在癫痫发病机制和治疗中作用的最新文献。此外，我们将简要介绍miRNA作为癫痫早期诊断和预后诊断生物标志物的潜力。
