霉菌毒素对黏膜微生物感染及相关发病机制的影响。
Effects of Mycotoxins on mucosal microbial infection and related pathogenesis.
作者信息
Park Seong-Hwan, Kim Dongwook, Kim Juil, Moon Yuseok
机构信息
Laboratory of Mucosal Exposome and Biomodulation, Department of Biomedical Sciences, Pusan National University School of Medicine, Yangsan 50612, Korea.
Research Institute for Basic Sciences and Medical Research Institute, Pusan National University, Busan 46241, Korea.
出版信息
Toxins (Basel). 2015 Oct 30;7(11):4484-502. doi: 10.3390/toxins7114484.
Mycotoxins are fungal secondary metabolites detected in many agricultural commodities and water-damaged indoor environments. Susceptibility to mucosal infectious diseases is closely associated with immune dysfunction caused by mycotoxin exposure in humans and other animals. Many mycotoxins suppress immune function by decreasing the proliferation of activated lymphocytes, impairing phagocytic function of macrophages, and suppressing cytokine production, but some induce hypersensitive responses in different dose regimes. The present review describes various mycotoxin responses to infectious pathogens that trigger mucosa-associated diseases in the gastrointestinal and respiratory tracts of humans and other animals. In particular, it focuses on the effects of mycotoxin exposure on invasion, pathogen clearance, the production of cytokines and immunoglobulins, and the prognostic implications of interactions between infectious pathogens and mycotoxin exposure.
霉菌毒素是在许多农产品和受水损害的室内环境中检测到的真菌次生代谢产物。对粘膜传染病的易感性与人类和其他动物接触霉菌毒素引起的免疫功能障碍密切相关。许多霉菌毒素通过减少活化淋巴细胞的增殖、损害巨噬细胞的吞噬功能和抑制细胞因子产生来抑制免疫功能，但有些霉菌毒素在不同剂量下会引发过敏反应。本综述描述了各种霉菌毒素对引发人类和其他动物胃肠道和呼吸道粘膜相关疾病的传染性病原体的反应。特别是，它重点关注霉菌毒素暴露对入侵、病原体清除、细胞因子和免疫球蛋白产生的影响，以及传染性病原体与霉菌毒素暴露之间相互作用的预后意义。
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