Babazadeh Arefeh, Mohseni Afshar Zeinab, Javanian Mostafa, Mohammadnia-Afrouzi Mousa, Karkhah Ahmad, Masrour-Roudsari Jila, Sabbagh Parisa, Koppolu Veerendra, Vasigala Veneela KrishnaRekha, Ebrahimpour Soheil
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R. Iran.
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Transl Int Med. 2019 Dec 31;7(4):137-142. doi: 10.2478/jtim-2019-0028. eCollection 2019 Dec.
Guillain-Barré syndrome (GBS) is an inflammatory disorder and an acute immune-mediated demyelinating neuropathy that causes reduced signal transmissions, progressive muscle weakness, and paralysis. The etiology of the syndrome still remains controversial and uncertain. GBS can be initiated and triggered by respiratory tract infections such as influenza, and intestinal infections such as . In addition, there is considerable evidence suggesting links between influenza vaccination and GBS. As reported previously, the incidence of GBS in individuals receiving swine flu vaccine was about one to two cases per million. Despite the influenza vaccine efficacy, its association with an immune-mediated demyelinating process can be challenging as millions of people get vaccinated every year. In this review we will discuss the association between influenza infection and vaccination with GBS by focusing on the possible immunopathological mechanisms.
格林-巴利综合征（GBS）是一种炎症性疾病，是一种急性免疫介导的脱髓鞘性神经病，可导致信号传递减少、进行性肌肉无力和瘫痪。该综合征的病因仍存在争议且不确定。GBS可由流感等呼吸道感染以及肠道感染引发。此外，有大量证据表明流感疫苗接种与GBS之间存在关联。如先前报道，接种猪流感疫苗的个体中GBS的发病率约为百万分之一至二例。尽管流感疫苗有效，但由于每年有数百万人接种疫苗，其与免疫介导的脱髓鞘过程的关联可能具有挑战性。在本综述中，我们将通过关注可能的免疫病理机制来讨论流感感染和疫苗接种与GBS之间的关联。
