Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
IBM Almaden Research Center, 650 Harry Road, San Jose, CA 95120, USA.
Adv Drug Deliv Rev. 2016 Mar 1;98:41-63. doi: 10.1016/j.addr.2015.10.014. Epub 2015 Oct 31.
Cancer is an extremely complex disease involving multiple signaling pathways that enable tumor cells to evade programmed cell death, thus making cancer treatment extremely challenging. The use of combination therapy involving both gene therapy and chemotherapy has resulted in enhanced anti-cancer effects and has become an increasingly important strategy in medicine. This review will cover important design parameters that are incorporated into delivery systems for the co-administration of drug and plasmid-based nucleic acids (pDNA and shRNA), with particular emphasis on polymers as delivery materials. The unique challenges faced by co-delivery systems and the strategies to overcome such barriers will be discussed. In addition, the advantages and disadvantages of combination therapy using separate carrier systems versus the use of a single carrier will be evaluated. Finally, future perspectives in the design of novel platforms for the combined delivery of drugs and genes will be presented.
癌症是一种极其复杂的疾病，涉及多个信号通路，使肿瘤细胞能够逃避程序性细胞死亡，从而使癌症治疗极具挑战性。联合基因治疗和化疗的联合治疗的应用导致了增强的抗癌效果，并已成为医学中越来越重要的策略。本综述将涵盖纳入药物和基于质粒的核酸（pDNA 和 shRNA）联合给药的递药系统中的重要设计参数，特别强调聚合物作为递药材料。将讨论共递药系统面临的独特挑战和克服这些障碍的策略。此外，将评估使用单独载体系统与使用单一载体进行联合治疗的优缺点。最后，将提出用于联合递药和基因的新型平台的设计的未来展望。
