Wang Lanqing, Mei Zi, Jin Guanyu, Liu Hao, Lv Shixian, Fu Runjia, Li Muxing, Yao Cuiping
Institute of Biomedical Photonics and Sensing, School of Life Science and Technology, Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.
School of Stomatology, School of Materials Science and Engineering, Department of General Surgery, Third Hospital, Peking University, Beijing, 100871, China.
Bioact Mater. 2024 Jul 5;36:541-550. doi: 10.1016/j.bioactmat.2024.06.034. eCollection 2024 Jun.
Systematic administration of small molecular drugs often suffered from the low efficacy and systemic toxicity in cancer therapy. In addition, application of single mode drug usually leads to unsatisfactory therapeutic outcomes. Currently, developing multimodal-drug combination strategy that acts on different pathways without increasing side effects remains great challenge. Here, we developed a hydrogel system that co-delivered glycolysis inhibitor apigenin and chemo-drug gemcitabine to realize combination strategy for combating cancer with minimal systemic toxicity. We demonstrated that this system can not only eliminate tumor cells , but also induce abscopal effect on various tumor models. These results showed that our study provided a safe and effective strategy for clinical cancer treatment.
在癌症治疗中，小分子药物的系统性给药常常存在疗效低和全身毒性的问题。此外，单一模式药物的应用通常会导致不尽人意的治疗效果。目前，开发一种多模式药物联合策略，在不增加副作用的情况下作用于不同途径，仍然是一个巨大的挑战。在此，我们开发了一种水凝胶系统，该系统共同递送糖酵解抑制剂芹菜素和化疗药物吉西他滨，以实现用最小的全身毒性对抗癌症的联合策略。我们证明，该系统不仅可以消除肿瘤细胞，还可以在各种肿瘤模型上诱导远隔效应。这些结果表明，我们的研究为临床癌症治疗提供了一种安全有效的策略。
