Maiyo Fiona, Singh Moganavelli
Non-Viral Gene & Drug Delivery Laboratory, Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, KwaZulu-Natal, South Africa.
Nanomedicine (Lond). 2017 May;12(9):1075-1089. doi: 10.2217/nnm-2017-0024. Epub 2017 Apr 25.
In recent decades, colloidal selenium nanoparticles have emerged as exceptional selenium species with reported chemopreventative and therapeutic properties. This has sparked widespread interest in their use as a carrier of therapeutic agents with results displaying synergistic effects of selenium with its therapeutic cargo and improved anticancer activity. Functionalization remains a critical step in selenium nanoparticles' development for application in gene or drug delivery. In this review, we highlight recent developments in the synthesis and functionalization strategies of selenium nanoparticles used in cancer drug and gene delivery systems. We also provide an update of recent preclinical studies utilizing selenium nanoparticles in cancer therapeutics.
近几十年来，胶体硒纳米颗粒已成为具有化学预防和治疗特性报道的特殊硒物种。这引发了人们对其作为治疗剂载体的广泛兴趣，结果显示硒与其治疗载荷具有协同作用，并提高了抗癌活性。功能化仍然是硒纳米颗粒在基因或药物递送应用开发中的关键步骤。在本综述中，我们重点介绍了用于癌症药物和基因递送系统的硒纳米颗粒的合成和功能化策略的最新进展。我们还提供了利用硒纳米颗粒进行癌症治疗的近期临床前研究的最新情况。
