Mela Christopher A, Patterson Carrie, Thompson William K, Papay Francis, Liu Yang
Department of Biomedical Engineering, The University of Akron, Akron, Ohio, United States of America.
John H. Glenn Research Center, Cleveland, Ohio, United States of America.
PLoS One. 2015 Nov 3;10(11):e0141956. doi: 10.1371/journal.pone.0141956. eCollection 2015.
We have developed novel stereoscopic wearable multimodal intraoperative imaging and display systems entitled Integrated Imaging Goggles for guiding surgeries. The prototype systems offer real time stereoscopic fluorescence imaging and color reflectance imaging capacity, along with in vivo handheld microscopy and ultrasound imaging. With the Integrated Imaging Goggle, both wide-field fluorescence imaging and in vivo microscopy are provided. The real time ultrasound images can also be presented in the goggle display. Furthermore, real time goggle-to-goggle stereoscopic video sharing is demonstrated, which can greatly facilitate telemedicine. In this paper, the prototype systems are described, characterized and tested in surgeries in biological tissues ex vivo. We have found that the system can detect fluorescent targets with as low as 60 nM indocyanine green and can resolve structures down to 0.25 mm with large FOV stereoscopic imaging. The system has successfully guided simulated cancer surgeries in chicken. The Integrated Imaging Goggle is novel in 4 aspects: it is (a) the first wearable stereoscopic wide-field intraoperative fluorescence imaging and display system, (b) the first wearable system offering both large FOV and microscopic imaging simultaneously,
我们开发了新型立体可穿戴多模态术中成像与显示系统，名为用于手术引导的集成成像护目镜。该原型系统具备实时立体荧光成像和彩色反射成像能力，以及体内手持式显微镜检查和超声成像功能。借助集成成像护目镜，可实现宽视野荧光成像和体内显微镜检查。实时超声图像也能在护目镜显示屏上呈现。此外，还展示了实时护目镜间的立体视频共享，这可极大地促进远程医疗。本文对该原型系统在离体生物组织手术中的情况进行了描述、表征和测试。我们发现该系统能够检测低至60 nM吲哚菁绿的荧光靶点，并且通过大视野立体成像能够分辨低至0.25毫米的结构。该系统已成功在鸡身上引导模拟癌症手术。集成成像护目镜在四个方面具有创新性：它是（a）首个可穿戴立体宽视野术中荧光成像与显示系统，（b）首个同时提供大视野和显微成像的可穿戴系统，
