Dos Anjos Silva Lindomar, Divino Flavia, da Silva Rêgo Márlisson Octávio, Lima Lopes Ivina Geselle, Nóbrega Costa Cláudia Maria, da Silva Pereira Francis Christian, de Filippis Ivano, Bello Gonzalo
1 Laboratório Central de Saúde Publica do Amapá (LACEN-AP) , Macapá, Brazil .
2 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz , FIOCRUZ, Rio de Janeiro, Brazil .
AIDS Res Hum Retroviruses. 2016 Apr;32(4):373-6. doi: 10.1089/AID.2015.0280. Epub 2015 Dec 1.
The pattern of HIV-1 subtype distribution and prevalence of transmitted drug resistance mutations (TDRM) is heterogeneous across different Brazilian regions. Little information is available about the molecular epidemiologic profile in Northern Brazil. HIV-1 protease (PR) and reverse transcriptase (RT) sequences were obtained from 97 drug-naive HIV-1-infected individuals from Amapá, one of the most isolated Northern Brazilian states, for subtype determination and analysis of drug resistance mutations. The most prevalent HIV-1 clade observed in Amapá was subtype B (74%), followed by subtype F1 (14%), BF1 recombinants (8%), subtype C (1%), CRF31_BC (1%), and CRF02_AG (1%). Only one TDRM (K103N) was detected in a single patient from our study population. This study reveals that the HIV-1 epidemic in Amapá is characterized by a high level of genetic diversity comparable to that observed in major Brazilian cities, but a much lower rate of TDRM (1%).
在巴西不同地区，HIV-1亚型分布模式以及传播性耐药突变（TDRM）的流行情况存在差异。关于巴西北部地区的分子流行病学概况，目前所知甚少。从巴西最偏远的北部州之一阿马帕的97名未接受过抗逆转录病毒治疗的HIV-1感染者中获取HIV-1蛋白酶（PR）和逆转录酶（RT）序列，用于亚型鉴定和耐药突变分析。在阿马帕观察到的最常见HIV-1分支是B亚型（74%），其次是F1亚型（14%）、BF1重组型（8%）、C亚型（1%）、CRF31_BC（1%）和CRF02_AG（1%）。在我们的研究人群中，仅在一名患者中检测到一种TDRM（K103N）。这项研究表明，阿马帕的HIV-1疫情具有高度的遗传多样性，与巴西主要城市相当，但TDRM发生率要低得多（1%）。
