Lehmann Helmar C, Höke Ahmet
Department of Neurology, University Hospital of Cologne, Cologne, Germany.
Department of Neurology, Johns-Hopkins Hospital, Baltimore, USA.
Brain Res. 2016 May 1;1638(Pt A):97-104. doi: 10.1016/j.brainres.2015.10.040. Epub 2015 Oct 31.
Many diseases of the peripheral nervous system affect the function of Schwann cells. Recent developments in stem cell technology offer the opportunity to engineer stem cell derived glial cell populations that reveal essential phenotypic characteristics of Schwann cells including growth support and myelination of peripheral axons. Potential applications of these cells include its use as platform for human cell-based disease models as well as potential source for cell transplantation strategies. In this review we provide an update on the latest developments in engineering Schwann cells as diagnostic tools or for cell replacement therapies in peripheral neuropathic conditions. This article is part of a Special Issue entitled PSC and the brain.
许多外周神经系统疾病会影响施万细胞的功能。干细胞技术的最新进展为构建源自干细胞的神经胶质细胞群体提供了机会，这些细胞群体展现出施万细胞的基本表型特征，包括对外周轴突的生长支持和髓鞘形成。这些细胞的潜在应用包括用作基于人类细胞的疾病模型平台以及细胞移植策略的潜在细胞来源。在本综述中，我们介绍了在构建施万细胞作为外周神经病变诊断工具或细胞替代疗法方面的最新进展。本文是名为“PSC与大脑”的特刊的一部分。
