Bittencourt Millena G, Kherani Saleema, Ferraz Daniel A, Ansari Mehreen, Nasir Humzah, Sepah Yasir J, Hanout Mostafa, Do Diana V, Nguyen Quan Dong
Retina Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, 1800 Orleans Street Woods 259-A, Baltimore, MD, 21287, USA.
Hospital das Clínicas, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255 Instituto Central, Cerqueira César, São Paulo, SP, CEP 05403-900, Brazil.
J Ophthalmic Inflamm Infect. 2014 Dec;4(1):14. doi: 10.1186/s12348-014-0014-z. Epub 2014 Aug 16.
Choroidal thickness (CTh) and choroidal vessel diameter (VD) in the Haler's layer were evaluated as markers of inflammatory insult in non-infectious uveitis (NIU). Spectral-domain optical coherence tomography (Spectralis®, Heidelberg Engineering Inc.) scans were acquired from 23 normal subjects (39 eyes - group 1), 7 subjects with high myopia (14 eyes - group 2), and 19 patients with NIU (23 eyes - group 3). In groups 1 and 2, CTh and VD were measured at 3 different points of the same horizontal OCT scan passing through the fovea and a mean calculated. Mean CTh and VD were calculated in 2 other locations, 2 mm superior and inferior from the chosen foveal horizontal scan. In group 3, three measurements of CTh and VD were obtained within 1 mm of a horizontal scan passing through a retinal lesion; mean CTh and VD were then computed. A ratio (R) between the VD and the corresponding CTh was calculated.
Group 1, 2 and 3 mean age was 29.6, 29.1 and 45.9 years, respectively. Sixteen normal subjects, three myopic subjects and six NIU patients were male.. Group 1 mean CTh did not differ from group 2 (261.6±45.6 vs. 260.2±50.6 µm µm; p>0.05); mean VD was marginally higher in Group 2 (159.8±32.2 vs. 163.2±33.2 µm; p>0.05). Group 3 demonstrated thinner CTh (193.6±54.6 µm) than Groups 1 and 2 (p = 0.02 and <0.001). Group 3 mean VD (123.6±37.4 µm) was also less than that in Groups 1 and 2; the difference was statistically significant only when compared to group 2, p = 0.01. R did not differ across groups (p-values >0.05), indicating that variations in CTh and VD followed the same trend.
The study reports potential quantitative OCT-derived parameters that may be explored in future trials of non-infectious uveitis. Thinning of choroid and decrease of vessel diameter are observed in patients with chronic NIU compared to controls.
评估哈勒氏层脉络膜厚度（CTh）和脉络膜血管直径（VD）作为非感染性葡萄膜炎（NIU）炎症损伤的标志物。使用光谱域光学相干断层扫描（Spectralis®，海德堡工程公司）对23名正常受试者（39只眼 - 第1组）、7名高度近视受试者（14只眼 - 第2组）和19名NIU患者（23只眼 - 第3组）进行扫描。在第1组和第2组中，在通过黄斑中心凹的同一水平OCT扫描的3个不同点测量CTh和VD，并计算平均值。在所选黄斑中心凹水平扫描上方和下方2 mm的另外两个位置计算平均CTh和VD。在第3组中，在通过视网膜病变的水平扫描的1 mm范围内获得CTh和VD的三次测量值；然后计算平均CTh和VD。计算VD与相应CTh之间的比值（R）。
第1组、第2组和第3组的平均年龄分别为29.6岁、29.1岁和45.9岁。16名正常受试者、3名近视受试者和6名NIU患者为男性。第1组的平均CTh与第2组无差异（261.6±45.6 vs. 260.2±50.6 µm；p>0.05）；第2组的平均VD略高（159.8±32.2 vs. 163.2±33.2 µm；p>0.05）。第3组的CTh（193.6±54.6 µm）比第1组和第2组薄（p = 0.02和<0.001）。第3组的平均VD（123.6±37.4 µm）也低于第1组和第2组；仅与第2组相比差异有统计学意义，p = 0.01。各组之间的R无差异（p值>0.05），表明CTh和VD的变化趋势相同。
该研究报告了潜在的基于OCT的定量参数，可在未来非感染性葡萄膜炎试验中进行探索。与对照组相比，慢性NIU患者观察到脉络膜变薄和血管直径减小。
