Basarir Berna, Celik Ugur, Altan Cigdem, Celik Nimet Burcu
Beyoglu Eye Research and Training Hospital, Istanbul, Turkey.
FEBO, Acibadem Hospital, Istanbul, Turkey.
Int Ophthalmol. 2018 Feb;38(1):307-312. doi: 10.1007/s10792-017-0464-z. Epub 2017 Feb 14.
To evaluate the choroidal thickness on acute anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis.
In this study, 32 eyes of 16 HLA-B27 positive AS patients with anterior uveitis and age-matched 19 eyes for control group were analyzed between January 2014 and April 2015. Assessment criteria were uveitis activity, visual acuity, flare existence, subfoveal choroidal thickness and central macular thickness measurements.
The mean subfoveal choroidal thicknesses in affected eye group (Group 1), unaffected eye group (Group 2) and control group (Group 3) were 348.31 ± 72.7, 301.12 ± 49.2 and 318.0 ± 74.3, respectively, in active periods. (p = 0.04 between Group 1 and Group 2, p = 0.234 between Group 1 and Group 3) The mean central macular thicknesses of Group 1, Group 2 and Group 3 were 268.50 ± 16.5, 267.31 ± 16.3 and 249.7 ± 30.5, respectively, in active periods. (p = 0.84 between Group 1 and Group 2, p = 0.029 between Group 1 and Group 3). However, in convalescence period, the mean subfoveal choroidal thicknesses of Group 1, Group 2 and Group 3 were 322.40 ± 48.5, 300.75 ± 47.7 and 318.0 ± 74.3, respectively. (p = 0.22 between Group 1 and Group 2, p = 0.854 between Group 1 and Group 3) The mean central macular thicknesses of Group 1, Group 2 and Group 3 were 269.75 ± 21.9, 256.62 ± 21.5 and 249.7 ± 30.5, respectively. (p = 0.09 between Group 1 and Group 2, p = 0.03 between Group 1 and Group 3).
In HLA-B27 positive ankylosing spondylitis patients with anterior uveitis, the choroidal thicknesses of the affected eyes were found as thicker than fellow unaffected one or control eyes in active period. The central macular thicknesses are not affected on both active and convalescent period.
评估HLA - B27阳性强直性脊柱炎患者急性前葡萄膜炎时的脉络膜厚度。
本研究分析了2014年1月至2015年4月期间16例患有前葡萄膜炎的HLA - B27阳性强直性脊柱炎患者的32只眼以及年龄匹配的19只眼作为对照组。评估标准包括葡萄膜炎活动度、视力、有无闪光、黄斑中心凹下脉络膜厚度及中心黄斑厚度测量。
在活动期，患眼组（第1组）、未患眼组（第2组）和对照组（第3组）的黄斑中心凹下平均脉络膜厚度分别为348.31±72.7、301.12±49.2和318.0±74.3。（第1组和第2组之间p = 0.04，第1组和第3组之间p = 0.234）第1组、第2组和第3组在活动期的平均中心黄斑厚度分别为268.50±16.5、267.31±16.3和249.7±30.5。（第1组和第2组之间p = 0.84，第1组和第3组之间p = 0.029）。然而，在恢复期，第1组、第2组和第3组的黄斑中心凹下平均脉络膜厚度分别为322.40±48.5、300.75±47.7和318.0±74.3。（第1组和第2组之间p = 0.22，第1组和第3组之间p = 0.854）第1组、第2组和第3组的平均中心黄斑厚度分别为269.75±21.9、256.62±21.5和249.7±30.5。（第1组和第2组之间p = 0.09，第1组和第3组之间p = 0.03）。
在患有前葡萄膜炎的HLA - B27阳性强直性脊柱炎患者中，发现患眼在活动期的脉络膜厚度比未受影响的对侧眼或对照眼更厚。在活动期和恢复期，中心黄斑厚度均未受影响。
