Tu Wenwei, Zheng Jian
Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Room L7-56, 7/F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong, China.
Methods Mol Biol. 2016;1371:157-76. doi: 10.1007/978-1-4939-3139-2_10.
During the past decade, the development of humanized mouse models and their general applications in biomedical research greatly accelerated the translation of outcomes obtained from basic research into potential diagnostic and therapeutic strategies in clinic. In this chapter, we firstly present an overview on the history and current progress of diverse humanized mouse models and then focus on those equipped with reconstituted human immune system. The update advancement in the establishment of humanized immune system mice and their applications in the studies of the development of human immune system and the pathogenesis of multiple human immune-related diseases are intensively reviewed here, while the shortcoming and perspective of these potent tools are discussed as well. As a valuable bridge across the gap between bench work and clinical trial, progressive humanized mouse models will undoubtedly continue to play an indispensable role in the wide area of biomedical research.
在过去十年中，人源化小鼠模型的发展及其在生物医学研究中的广泛应用极大地加速了从基础研究获得的成果向临床潜在诊断和治疗策略的转化。在本章中，我们首先概述各种人源化小鼠模型的历史和当前进展，然后重点介绍配备重建人免疫系统的模型。本文将深入综述人源化免疫系统小鼠建立方面的最新进展及其在人类免疫系统发育和多种人类免疫相关疾病发病机制研究中的应用，同时也将讨论这些强大工具的缺点和前景。作为跨越基础研究和临床试验之间差距的宝贵桥梁，不断进步的人源化小鼠模型无疑将继续在广泛的生物医学研究领域发挥不可或缺的作用。
