Safinia N, Becker P D, Vaikunthanathan T, Xiao F, Lechler R, Lombardi G
MRC Centre for Transplantation, King's College London, Guy's Hospital, 5th Floor Tower Wing, London, SE1 9RT, UK.
Methods Mol Biol. 2016;1371:177-96. doi: 10.1007/978-1-4939-3139-2_11.
Animal models have been instrumental in our understanding of the mechanisms of rejection and the testing of novel treatment options in the context of transplantation. We have now entered an exciting era with research on humanized mice driving advances in translational studies and in our understanding of the function of human cells in response to pathogens and cancer as well as the recognition of human allogeneic tissues in vivo. In this chapter we provide a historical overview of humanized mouse models of transplantation to date, outlining the distinct strains and share our experiences in the study of human transplantation immunology.
动物模型在我们理解移植排斥机制以及测试新型治疗方案方面发挥了重要作用。随着对人源化小鼠的研究推动了转化研究的进展，以及我们对人类细胞在应对病原体和癌症时的功能的理解，还有对体内人类同种异体组织的识别，我们现在进入了一个令人兴奋的时代。在本章中，我们提供了迄今为止移植人源化小鼠模型的历史概述，概述了不同的品系，并分享了我们在人类移植免疫学研究中的经验。
