Corkhill P H, Hamilton C J, Tighe B J
Department of Applied Chemistry and Chemical Engineering, Aston University, Birmingham, UK.
Biomaterials. 1989 Jan;10(1):3-10. doi: 10.1016/0142-9612(89)90002-1.
An overview is presented of the use of hydrogel composites as biomaterials. These range from laminates or coatings (in which a homogeneous hydrogel is used in conjunction with a more mechanically stable substrate), through blends of hydrogels with synthetic hydrophobic polymers, to the use of two-component systems in which water enhances the compatibility of two structurally different polymers. Although synthetic hydrogels provide an ideal basis for materials of these types, naturally occurring hydrophilic polymers with their unique properties have a major contribution to make. It is in the clinical and patent literature, rather than journals dealing with polymers per se, that the vast majority of examples of the use of hydrogel composites are found. This review collects and comments on examples based on synthetic developments in this field during the last decade, particularly in relation to the development of wound dressings and implant materials.
本文概述了水凝胶复合材料作为生物材料的应用。这些材料包括层压板或涂层（其中均匀的水凝胶与机械稳定性更高的基材结合使用），从水凝胶与合成疏水性聚合物的共混物，到使用双组分体系，其中水增强了两种结构不同的聚合物的相容性。尽管合成水凝胶为这些类型的材料提供了理想的基础，但具有独特性能的天然亲水性聚合物也做出了重大贡献。绝大多数水凝胶复合材料的应用实例见于临床和专利文献，而非专门论述聚合物的期刊。本综述收集并评论了基于该领域过去十年合成技术发展的实例，特别是与伤口敷料和植入材料的发展相关的实例。
